Comparison of the analgesic effect of intravenous acetaminophen with that of flurbiprofen axetil on post-breast surgery pain: a randomized controlled trial
| Autor: | Marie Hara, Takahiro Nonaka, Chisato Miyamoto, Tatsuo Yamamoto, Michiko Sugita |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Visual analogue scale Breast surgery medicine.medical_treatment Flurbiprofen Analgesic law.invention 03 medical and health sciences 0302 clinical medicine Patient satisfaction Double-Blind Method Randomized controlled trial 030202 anesthesiology law medicine Humans Breast Mastectomy Acetaminophen Aged Pain Measurement Pain Postoperative business.industry Anti-Inflammatory Agents Non-Steroidal Analgesics Non-Narcotic Middle Aged Surgery Anesthesiology and Pain Medicine Patient Satisfaction Anesthesia Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Anesthesia. 30:405-409 |
| ISSN: | 1438-8359 0913-8668 |
| DOI: | 10.1007/s00540-016-2150-0 |
| Popis: | Acetaminophen is known to be a relatively weak analgesic with fewer side effects than nonsteroidal anti-inflammatory drugs (NSAIDs). This study aimed to determine whether intravenous (iv) acetaminophen produces comparable analgesic effects to those of flurbiprofen (positive control drug), an intravenously injectable NSAID, after partial mastectomies. The primary outcome assessed was pain intensity during the first 24 h after the operation, and the secondary outcome was the satisfaction rating at discharge. After obtaining Institutional Ethics Committee approval, a series of 40 consecutive female patients who were scheduled for partial mastectomies were enrolled. Participants were randomly divided into two groups: an acetaminophen (1000 mg × 3) group (group A) and a flurbiprofen (50 mg × 3) group (group F). Each drug was administered 15 min before the end of surgery, and at 6 and 12 h after the operation. Postoperative pain was evaluated using a 100-mm visual analog scale (VAS) at 3, 6, and 24 h postoperatively. Satisfaction rating was evaluated on a 5-point scale (very good, good, well, bad, and very bad). VAS scores (mm) with movement in groups A and F at 3, 6, and 24 h after the surgery were 22 vs. 28, 14 vs. 24, and 12 vs. 20.5 (median), respectively, with no significant differences between the two groups. Eighteen of 20 patients in group A and 20 of 20 patients in group F expressed a satisfaction rating of greater than good. Acetaminophen produces an equivalent analgesic effect to flurbiprofen in post-partial mastectomy patients. |
| Databáze: | OpenAIRE |
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