Right heart mechanics in untreated normotensive patients with prediabetes and type 2 diabetes mellitus: a two- and three-dimensional echocardiographic study
| Autor: | Cesare Cuspidi, Branislava Ivanovic, Tamara Marjanovic, Sanja Ilic, Vera Celic, Dejana Stanisavljevic, Gonenc Kocabay, Marijana Tadic, Biljana Pencic, Jana Radojkovic |
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| Přispěvatelé: | Tadic, M, Celic, V, Cuspidi, C, Ilic, S, Pencic, B, Radojkovic, J, Ivanovic, B, Stanisavljevic, D, Kocabay, G, Marjanovic, T |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Diabetes mellitu Ventricular Dysfunction Right Echocardiography Three-Dimensional Speckle-tracking imaging Three-dimensional echocardiography Right atrial Sensitivity and Specificity Prediabetic State chemistry.chemical_compound Internal medicine Diabetes mellitus Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Prediabetes Body surface area Right atrium business.industry Type 2 Diabetes Mellitus Reproducibility of Results Stroke Volume Mechanics Middle Aged medicine.disease chemistry Diabetes Mellitus Type 2 Right heart Prediabete Cardiology Right ventricle Elasticity Imaging Techniques Female Glycated hemoglobin MED/09 - MEDICINA INTERNA Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 28(3) |
| ISSN: | 1097-6795 |
| Popis: | Background: The aim of this study was to determine right ventricular (RV) and right atrial (RA) deformation assessed by two-dimensional echocardiographic and three-dimensional echocardiographic (3DE) imaging in patients with prediabetes and type 2 diabetes mellitus. Methods: This cross-sectional study included 47 untreated normotensive subjects with prediabetes, 57 recently diagnosed normotensive patients with diabetes, and 54 healthy controls of similar sex and age distributions. All subjects underwent laboratory analyses and complete two-dimensional echocardiographic and 3DE examinations. Results: Three-dimensional echocardiographic RV end-diastolic volume index gradually decreased from controls across patients with diabetes to those with diabetes (69 ± 10 vs 63 ± 8 vs 58 ± 8mL/m2, P < .001), whereas 3DE RV end-systolic volume index was higher in controls compared with patients with diabetes and those with diabetes (25 ± 4 vs 23 ± 4vs 22 ± 4mL/m2, P < .001). However, there was no difference in 3DE RV ejection fraction among the three groups (63 ± 4% vs 62 ± 4% vs 61 ± 5%, P = .063). RV and RA global strain and systolic and early diastolic strain rates were decreased in patients with prediabetes and in those with diabetes compared with controls, whereas RV and RA late diastolic strain rates were increased in these patients. Multivariate regression analysis showed that RV global strain was associated with glycated hemoglobin, independent of left ventricular parameters. Conclusions: RV and RA myocardial deformation and function obtained by 3DE and two-dimensional echocardiographic strain, even in normal ranges, were decreased in patients with prediabetes and in those with diabetes compared with controls. The long-term parameter of glucose control was correlated with the right heart mechanics. |
| Databáze: | OpenAIRE |
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