Bidirectional gastric differentiation in cellular mucin phenotype (foveolar and pyloric) in serrated adenoma and hyperplastic polyp of the colorectum
| Autor: | Yoichiro Baba, Yoichi Ajioka, Gen Mukai, Terasu Honma, Ken Nishikura, Haruka Hirono, Hidenobu Watanabe, Erica Tozawa, Yutaka Aoyagi |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adenoma
Pathology medicine.medical_specialty Crypt Colonic Polyps Mucin 5AC Biology Pathology and Forensic Medicine Tubular adenoma Antigens Neoplasm medicine Humans Mucin-6 Antrum Hyperplasia Mucin Mucins General Medicine medicine.disease digestive system diseases Foveolar cell Cell Transformation Neoplastic Hyperplastic Polyp Gastric Mucosa Colorectal Neoplasms Immunostaining |
| Zdroj: | Pathology International. 54:401-407 |
| ISSN: | 1440-1827 1320-5463 |
| DOI: | 10.1111/j.1440-1827.2004.01639.x |
| Popis: | This study examined whether gastric pyloric gland-type mucin is expressed in serrated adenoma (SA) and in hyperplastic polyp (HP) of the colorectum, and whether cellular position-based gastric differentiation is observed in these lesions as previously hypothesized. Immunostaining was performed for MUC6 and alpha-linked GlcNAc residue (pyloric gland-type mucin markers), human gastric mucin (HGM; foveolar-type mucin marker) and Ki-67 (proliferating cell marker) for 31 SA, 22 HP, 21 traditional tubular adenoma (TA) and 20 hyperplastic nodule (HN). MUC6 showed varying expression in SA, 22/31 (71.0%); HP, 15/22 (68.2%); TA, 2/21 (9.5%); and HN, 0/20 (0%) with significantly higher frequencies in SA and HP compared to those in TA and HN. The alpha-linked GlcNAc residue was found only in SA (3/31, 9.7%) and in HP (2/22, 9.1%). In SA and HP, HGM was typically expressed in the entire crypt length, but some reduction in expression was shown in the basal crypt portion below the proliferative zone. MUC6 and alpha-linked GlcNAc residues were expressed in the basal crypt portion below or below and including proliferative zone. These data demonstrate that SA and HP show bidirectional gastric (foveolar and pyloric gland) differentiation with respect to mucin cellular phenotype and the potential for cellular position-based differentiation, which mimics the gastric antral mucosa. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|