Comparison and interaction of morphine and CB1 agonist conditioned place preference in the rat model of early life stress
| Autor: | Ali Karimi Goudarzi, Sarah Mahboubi, Mohammad-Reza Zarrindast, Setareh Nouri Zadeh-Tehrani, Ardeshir Akbarabadi, Fardad Pirri, Mitra-Sadat Sadat-Shirazi |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Narcotics Agonist medicine.medical_specialty Cannabinoid receptor medicine.drug_class medicine.medical_treatment Arachidonic Acids Nucleus accumbens Cannabinoidergic Extinction Psychological 03 medical and health sciences 0302 clinical medicine Reward Developmental Neuroscience Internal medicine medicine Animals Inverse agonist Drug Interactions Rats Wistar 030304 developmental biology Cannabinoid Receptor Agonists 0303 health sciences Morphine business.industry Maternal Deprivation Conditioned place preference Rats Endocrinology Conditioning Operant Female Cannabinoid business 030217 neurology & neurosurgery Developmental Biology medicine.drug |
| Zdroj: | International Journal of Developmental Neuroscience. 81:238-248 |
| ISSN: | 1873-474X 0736-5748 |
| DOI: | 10.1002/jdn.10094 |
| Popis: | Early life stress (ELS) disrupts brain development and subsequently affects physical and psychological health. ELS has been associated with an increased risk of relapse and inadequate treatment response in addicted patients. The current study was designed to find the effect of ELS on the rewarding effect of morphine and cannabinoid and their interaction. Pregnant female Wistar rats were used in this study. On postnatal day 2 (PND2), pups were separated from their mothers for 3 hr daily. This procedure was repeated every day at the same time until PND 14. The control group was kept in the standard nesting way with their mothers. The adult male offspring of maternal separated (MS) and standard nested (SN) rats were used. Using conditioned place preference task (CPP), the rewarding effect of morphine (0.75, 1.25, 2.5, and 5 mg/kg) was evaluated in both MS and SN groups. Besides, the rewarding effect of cannabinoids was investigated using the administration of CB1 receptor agonist (ACPA, 0.25, 0.5, 1 µg/rat) and inverse agonist (AM-251, 30, 60, and 90 ng/rat) in the nucleus accumbens (NAc). To evaluate the interaction between NAc cannabinoidergic system and morphine, the noneffective dose of ACPA and AM-251 were administered with a noneffective dose of morphine (0.75 mg/kg) on both MS and SN animals. Obtained results indicated that MS groups had a leftward shift in the rewarding effect of morphine and conditioned with low doses of morphine. However, they had a rightward shift in the rewarding effect of cannabinoids. In addition, coadministration of noneffective doses of morphine and ACPA potentiate conditioning in both MS and SN groups. Previous evidence shows that ELS induced changes in the brain, especially in the reward circuits. Here, we demonstrated that MS animals are more sensitive to the rewarding effect of morphine compared with SN animals. In addition, ELS disrupts the cannabinoid system and affect the rewarding effect of cannabinoids. |
| Databáze: | OpenAIRE |
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