Centrally administered ouabain aggravates central sleep apneas
| Autor: | Kaba H, Takayuki Sato, H. Takatsuji, M. Tadokoro, Katsuo Seto, H. Saito |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Respiratory rate Physiology Central nervous system Rapid eye movement sleep Sleep REM Blood Pressure Digitalis Rats Inbred WKY Ouabain Sleep Apnea Syndromes Physiology (medical) Internal medicine medicine Animals Rats Wistar Injections Intraventricular Sleep disorder Dose-Response Relationship Drug biology business.industry Electroencephalography medicine.disease biology.organism_classification Sleep in non-human animals Rats Electrooculography Endocrinology medicine.anatomical_structure Cerebral ventricle business medicine.drug |
| Zdroj: | Journal of Applied Physiology. 74:545-548 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | The presence of endogenous digitalis-like factors in the central nervous system suggests their functional significance in the central nervous system. Three-day infusions of three-stepped doses of the digitalis agent ouabain (1–100 ng.kg body wt-1.h-1) into the lateral cerebral ventricle of freely moving rats caused a dose-dependent increase in the number of central-apneic episodes during rapid-eye-movement sleep without affecting the time spent in rapid-eye-movement sleep or basic respiratory rate. These results suggest that endogenous digitalis-like factors may be involved in the genesis of central sleep apneas. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|