Centrally administered ouabain aggravates central sleep apneas

Autor: Kaba H, Takayuki Sato, H. Takatsuji, M. Tadokoro, Katsuo Seto, H. Saito
Rok vydání: 1993
Předmět:
Zdroj: Journal of Applied Physiology. 74:545-548
ISSN: 1522-1601
8750-7587
Popis: The presence of endogenous digitalis-like factors in the central nervous system suggests their functional significance in the central nervous system. Three-day infusions of three-stepped doses of the digitalis agent ouabain (1–100 ng.kg body wt-1.h-1) into the lateral cerebral ventricle of freely moving rats caused a dose-dependent increase in the number of central-apneic episodes during rapid-eye-movement sleep without affecting the time spent in rapid-eye-movement sleep or basic respiratory rate. These results suggest that endogenous digitalis-like factors may be involved in the genesis of central sleep apneas.
Databáze: OpenAIRE