Subcutaneous alemtuzumab for Sézary Syndrome in the very elderly
| Autor: | Pierluigi Porcu, Larisa J. Geskin, Terrence Grady, Robert A. Baiocchi, Lapo Alinari, Mark A. Bechtel |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Antibodies Neoplasm Injections Subcutaneous Congenital cytomegalovirus infection Antineoplastic Agents Antibodies Monoclonal Humanized Malignancy Asymptomatic Gastroenterology Virus Older patients Internal medicine medicine Humans Sezary Syndrome Alemtuzumab Aged 80 and over biology business.industry Antibodies Monoclonal Hematology medicine.disease Oncology Monoclonal Immunology biology.protein Female medicine.symptom Antibody business medicine.drug |
| Zdroj: | Leukemia Research. 32:1299-1303 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2007.11.009 |
| Popis: | Sézary Syndrome (SS) is an aggressive T-cell malignancy often presenting in advanced age and associated with poor prognosis. There is no standard therapy and because of co-morbidities, elderly patients are particularly challenging to treat. Alemtuzumab is an anti-CD52 monoclonal antibody that has activity in SS but is profoundly immunosuppressive, leading to great hesitation about its use in older patients. We treated five octogenarian patients with SS with subcutaneous (SQ) alemtuzumab, at relapse or as initial therapy, for 5-9 weeks. With the exception of transient grade 1-2 hematological toxicity and asymptomatic cytomegalovirus (CMV) (two patients) and Epstein-Barr virus (EBV) (one patient) reactivation, no other toxicities were observed. The clinical and hematological complete response (CR) rate was 100%. Three patients achieved durable responses (8+ to 17+ months). Alemtuzumab was safely administered and showed significant activity in very elderly SS patients. |
| Databáze: | OpenAIRE |
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