Assessment of myocardial viability with [15O]water PET : A validation study in experimental myocardial infarction
| Autor: | Mika Teräs, Tuomas Kiviniemi, Miikka Tarkia, Paavo Halonen, Virva Saunavaara, Antti Kuivanen, Christoffer Stark, Juhani Knuuti, Tuula Tolvanen, Seppo Ylä-Herttuala, Antti Saraste, Mikko Pietilä, Tommi Vähäsilta, Timo Savunen, Anne Roivainen, Mark Lubberink, Maria Grönman, Jarmo Teuho |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Perfusion scanning 030204 cardiovascular system & hematology Anterior Descending Coronary Artery Chest pain 030218 nuclear medicine & medical imaging 03 medical and health sciences Myocardial perfusion imaging 0302 clinical medicine Internal medicine medicine Radiology Nuclear Medicine and imaging Cardiac and Cardiovascular Systems Myocardial infarction Radiowater Ejection fraction Kardiologi medicine.diagnostic_test business.industry viability Area under the curve myocardial perfusion imaging medicine.disease PET myocardial infarction Cardiology Radiologi och bildbehandling medicine.symptom Cardiology and Cardiovascular Medicine business Perfusion circulatory and respiratory physiology Radiology Nuclear Medicine and Medical Imaging |
| Popis: | Background Assessment of myocardial viability is often needed in patients with chest pain and reduced ejection fraction. We evaluated the performance of reduced resting MBF, perfusable tissue fraction (PTF), and perfusable tissue index (PTI) in the assessment of myocardial viability in a pig model of myocardial infarction (MI). Methods and results Pigs underwent resting [15O]water PET perfusion study 12 weeks after surgical (n = 16) or 2 weeks after catheter-based (n = 4) occlusion of the proximal left anterior descending coronary artery. MBF, PTF, and PTI were compared with volume fraction of MI in matched segments as assessed by triphenyl tetrazolium chloride staining of LV slices. MBF and PTF were lower in infarcted than non-infarcted segments. Segmental analysis of MBF showed similar area under the curve (AUC) of 0.85, 0.86, and 0.90 with relative MBF, PTF, and PTI for the detection of viable myocardium defined as infarct volume fraction of < 75%. Cut-off values of relative MBF of ≥ 67% and PTF of ≥ 66% resulted in accuracies of 90% and 81%, respectively. Conclusions Our results indicate that resting MBF, PTF, and PTI based on [15O]water PET perfusion imaging are useful for the assessment of myocardial viability. |
| Databáze: | OpenAIRE |
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