Meta-analysis of genome-wide association data detects a risk locus for major mood disorders on chromosome 3p21.1
| Autor: | Florian Holsboer, Jens R. Wendland, René Breuer, Sevilla D. Detera-Wadleigh, Manuel Mattheisen, Pierandrea Muglia, Sven Cichon, Markus M. Nöthen, John B. Vincent, Jana Strohmaier, C. J. M. Steele, Thomas W. Mühleisen, Federica Tozzi, Anne Farmer, Marcella Rietschel, Nirmala Akula, Wolfgang Maier, Martin Preisig, Thomas G. Schulze, Francis J. McMahon |
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| Přispěvatelé: | Bipolar Disorder Genome Study (BiGS) Consortium |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Chromosomes
Human Pair 3/genetics Genetic Loci/genetics Genetic Predisposition to Disease Genome-Wide Association Study Humans Mood Disorders/genetics Polymorphism Single Nucleotide/genetics Genome-wide association study Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Article PBRM1 03 medical and health sciences 0302 clinical medicine mental disorders Genetics medicine Bipolar disorder 030304 developmental biology Genetic association STAB1 0303 health sciences Mood Disorders GNL3 NT5DC2 ITIH Odds ratio GLT8D1 medicine.disease bipolar Mood Mood disorders Genetic Loci depression Major depressive disorder Chromosomes Human Pair 3 GAIN 030217 neurology & neurosurgery SPCS1 NEK4 |
| Zdroj: | Nature genetics Nature genetics, vol. 42, no. 2, pp. 128-131 |
| ISSN: | 1546-1718 1061-4036 |
| Popis: | The major mood disorders, which include bipolar disorder (BD) and major depressive disorder (MDD), are substantially heritable, but few risk loci have been identified. We performed a meta-analysis of 5 major mood disorder case-control samples, including over 13,600 unique individuals genotyped with approximately 500,000 to 1 million single nucleotide polymorphism (SNP) markers on high-density arrays. Allele-wise association results were meta-analyzed with a method that weights results by sample size. We found genome-wide significant evidence that SNPs in a region of chromosome 3p21.1were associated with major mood disorders. The SNP rs2251219 returned the smallest meta-analysis p-value, 3.63 × 10−8, with a pooled odds ratio of 0.87. Supportive results were observed in 2 out of 3 independent samples tested in a replication study. These results implicate one or more genes in this region in the etiology of major mood disorders and suggest that BD and MDD share genetic risk factors. |
| Databáze: | OpenAIRE |
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