Photodynamic therapy and/or external beam radiation therapy for roentgenologically occult lung cancer
| Autor: | Sumitaka Imamura, Nobuhide Takifuji, Shinei Ryu, Shunichi Negoro, Kaoru Matsui, Yoko Kusunoki, Noriyuki Masuda, Minoru Takada, Shinzoh Kudo, Masahiro Fukuoka |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Photodynamic therapy medicine Carcinoma Humans Hematoporphyrin Derivative Neoplasm Invasiveness Lung cancer Aged Lung Epithelioma business.industry Remission Induction Respiratory disease Middle Aged medicine.disease Combined Modality Therapy Occult Surgery Airway Obstruction Survival Rate Radiation therapy medicine.anatomical_structure Photochemotherapy Oncology Carcinoma Squamous Cell Neoplasms Unknown Primary Female Laser Therapy Radiology Neoplasm Recurrence Local business Carcinoma in Situ Follow-Up Studies |
| Zdroj: | Cancer. 73:1608-1614 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19940315)73:6<1608::aid-cncr2820730611>3.0.co;2-1 |
| Popis: | Background and Methods. Thirty-nine roentgenologically occult lung cancers in 29 patients were treated using photodynamic therapy (PDT) and/or thoracic radiotherapy (TRT) from January 1986 to March 1992. With the exception of one mixed-tumor case, all were squamous cell carcinomas. Results. Initial PDT achieved complete responses in 25 of 39 (64%) of the cancers. Of the remaining 14 cancers that showed less than complete response (CR), 10 of the 14 (71.4%) showed a CR when subsequently treated with TRT, yielding an overall CR rate of 89.7% for cancers treated. Although nine patients experienced recurrences, six of these had CR when treated with PDT and/or TRT. To date, 22 patients are alive. Causes of death in the patients enrolled in this study are as follows: pyothorax (2); heart failure due to pulmonary hypertension (1); chronic respiratory insufficiency (1); subsequent primary brain cancer (1); and subsequent primary lung cancer (1). Only one died of primary lung cancer. Conclusions. These findings suggest that PDT and/or TRT may be used as an alternative to surgery in the treatment of selected patients with roentgenologically occult lung cancer. |
| Databáze: | OpenAIRE |
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