Anticardiolipin IgG Antibody and Homocysteine as Possible Risk Factors for Retinal Vascular Occlusive Disease in Thai Patients
| Autor: | Parapun Bumrungsuk, Warapat Wongsawad, Adisak Trinavarat, La-ongsri Atchaneeyasakul |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Adolescent Homocysteine Retinal Artery Occlusion chemistry.chemical_compound Risk Factors Retinal Vein Occlusion Humans Medicine Anticardiolipin IgG Antibody Vascular occlusive disease Aged Retrospective Studies biology business.industry Retrospective cohort study Retinal General Medicine Middle Aged Thailand Ophthalmology chemistry Antibodies Anticardiolipin Immunoglobulin G Immunology biology.protein Plasma homocysteine Female Anticardiolipin antibodies Antibody business |
| Zdroj: | Japanese Journal of Ophthalmology. 49:211-215 |
| ISSN: | 1613-2246 0021-5155 |
| DOI: | 10.1007/s10384-005-0190-3 |
| Popis: | To assess the role of serum anticardiolipin IgG antibody and fasting plasma homocysteine levels as risk factors for retinal vascular occlusive disease in Thai patients.This is a retrospective, case-control study. Forty-one consecutive patients with recent onset of retinal vascular occlusive diseases were enrolled. In conjunction with a routine laboratory work up, serum anticardiolipin IgG antibody and plasma homocysteine were evaluated. Ninety volunteers without a history of retinal vascular occlusive disease were chosen as controls.In general, mean levels of anticardiolipin IgG antibody and homocysteine did not differ between the patients and controls. However, when the groups without a history of underlying systemic diseases were compared, there were statistically significant differences in the anticardiolipin IgG antibody level between patients and controls (mean 12.24 +/- 8.66 and 7.70 +/- 6.69 GPL units/ml, respectively) with a P value of 0.024.No association was found between plasma homocysteine level and retinal vascular occlusion in our patient population. A high level of anticardiolipin IgG antibody is shown to be a risk factor only in patients without a history of underlying systemic diseases. The effect of anticardiolipin IgG antibody on the development of retinal vascular occlusive disease appears to be limited and may not be a major cause. |
| Databáze: | OpenAIRE |
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