Neuroepidemiologic Research Initiatives on Guam: Past and Present
| Autor: | W.C. Wiederholt |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Epidemiology business.industry Incidence (epidemiology) Amyotrophic Lateral Sclerosis Neurodegenerative Diseases Parkinson Disease Disease History 20th Century medicine.disease Guam Etiology Animals Humans Medicine Dementia Neuroepidemiology Neurology (clinical) Parkinsonian features Amyotrophic lateral sclerosis business Psychiatry Demography |
| Zdroj: | Neuroepidemiology. 18:279-291 |
| ISSN: | 1423-0208 0251-5350 |
| DOI: | 10.1159/000026223 |
| Popis: | Since the middle of this century, a remarkable concentration of cases of neurodegenerative disease(s), referred to as amyotrophic lateral sclerosis and Parkinson-dementia complex (ALS/PDC), has been recognized among Chamorro natives of Guam. Intense investigations over the last 4 decades have failed to determine the etiology of these invariably fatal diseases. Over the same time period, the incidence of ALS has decreased dramatically, the incidence of PDC has decreased, but to a lesser degree, and age at onset has shifted to a later age by about 1 decade. Almost 50% of demented patients present without the classical Parkinsonian features of PDC, and the morphological picture has changed. Results of past and present research initiatives are reviewed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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