Can curcumin supplementation reduce plasma levels of gut-derived uremic toxins in hemodialysis patients? A pilot randomized, double-blind, controlled study
| Autor: | Lia S. Nakao, Roberta Salarolli, Laís de Souza Gouveia Moreira, Livia Alvarenga, Ludmila F M F Cardozo, Denis Fouque, Jordana Dinorá de Lima, Denise Mafra, Silvia D. Rodrigues, Karla Thaís Resende Teixeira |
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| Přispěvatelé: | Fluminense Federal University [Niterói], Federal University of Technology - Paraná (UTFPR), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CarMeN, laboratoire |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nephrology
Male medicine.medical_treatment [SDV]Life Sciences [q-bio] 030232 urology & nephrology Pilot Projects 030204 cardiovascular system & hematology Gut flora Gastroenterology chemistry.chemical_compound Cresols 0302 clinical medicine Chronic kidney disease biology Middle Aged 3. Good health [SDV] Life Sciences [q-bio] Hemodialysis Uremic toxins Female Adult medicine.medical_specialty Curcumin Urology Gut microbiota Sulfuric Acid Esters 03 medical and health sciences Double-Blind Method Renal Dialysis Internal medicine medicine Humans Dialysis Aged Toxins Biological Uremia Orange juice Indoleacetic Acids business.industry biology.organism_classification medicine.disease Gastrointestinal Microbiome chemistry Dietary Supplements business Indican Kidney disease |
| Zdroj: | International Urology and Nephrology International Urology and Nephrology, Springer Verlag, 2021, 53 (6), pp.1231-1238. ⟨10.1007/s11255-020-02760-z⟩ |
| ISSN: | 0301-1623 1573-2584 |
| Popis: | International audience; BACKGROUND: Gut dysbiosis is common in patients with chronic kidney disease (CKD) and is closely related to inflammatory processes. Some nutritional strategies, such as bioactive compounds present in curcumin, have been proposed as an option to modulate the gut microbiota and decrease the production of uremic toxins such as indoxyl sulfate (IS), p-cresyl sulfate (pCS) and indole-3 acetic acid (IAA). OBJECTIVE: To evaluate the effects of curcumin supplementation on uremic toxins plasma levels produced by gut microbiota in patients with CKD on hemodialysis (HD). METHODS: Randomized, double-blind trial in 28 patients [53.6 ± 13.4 years, fourteen men, BMI 26.7 ± 3.7 kg/m(2), dialysis vintage 37.5 (12-193) months]. Fourteen patients were randomly allocated to the curcumin group and received 100 mL of orange juice with 12 g carrot and 2.5 g of turmeric and 14 patients to the control group who received the same juice but without turmeric three times per week after HD sessions for three months. IS, pCS, IAA plasma levels were measured by reverse-phase high-performance liquid chromatography RESULTS: After three months of supplementation, the curcumin group showed a significant decrease in pCS plasma levels [from 32.4 (22.1-45.9) to 25.2 (17.9-37.9) mg/L, p = 0.009], which did not occur in the control group. No statistical difference was observed in IS and IAA levels in both groups. CONCLUSION: The oral supplementation of curcumin for three months seems to reduce p-CS plasma levels in HD patients, suggesting a gut microbiota modulation. |
| Databáze: | OpenAIRE |
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