Optical coherence tomography in acute optic neuritis: A population-based study
Autor: | Svenja Specovius, Jakob Grauslund, Alexander U. Brandt, Clement Olesen, Hanna Zimmermann, Kerstin Soelberg, Jesper Mehlsen, Allan S B Neve, Friedemann Paul, Nasrin Asgari |
---|---|
Rok vydání: | 2018 |
Předmět: |
Adult
Male medicine.medical_specialty Visual acuity Optic Neuritis genetic structures Denmark Population Nerve fiber layer multiple sclerosis Myelin oligodendrocyte glycoprotein 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology medicine Humans autoimmune diseases Optic neuritis Prospective Studies education optic neuritis education.field_of_study optical coherence tomography biology business.industry Multiple sclerosis Retinal General Medicine Middle Aged medicine.disease eye diseases Ganglion medicine.anatomical_structure Neurology chemistry 030221 ophthalmology & optometry biology.protein myelin oligodendrocyte glycoprotein autoantibodies Female sense organs Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Tomography Optical Coherence |
Zdroj: | Soelberg, K, Specovius, S, Zimmermann, H G, Grauslund, J, Mehlsen, J J, Olesen, C, Neve, A S B, Paul, F, Brandt, A U & Asgari, N 2018, ' Optical coherence tomography in acute optic neuritis : A population-based study ', Acta Neurologica Scandinavica, vol. 138, no. 6, pp. 566-573 . https://doi.org/10.1111/ane.13004 |
ISSN: | 1600-0404 |
DOI: | 10.1111/ane.13004 |
Popis: | OBJECTIVES: To measure early structural damage caused by autoimmune inflammatory optic neuritis (ON) by optical coherence tomography (OCT) in a population-based cohort.METHODS: In a prospective population-based study over 24 months in Southern Denmark, patients diagnosed with acute ON and without prior diagnosis of a chronic neuroinflammatory disorder were included and examined with OCT, visual evoked potentials (VEP), visual fields, high contrast visual acuity (HCVA), and low contrast letter acuity (LCLA). Structural and functional outcomes were determined at 6-month follow-up based on interocular differences.RESULTS: The 50 included patients had on average 16.9 μm peripapillary retinal nerve fiber layer loss, 10.6 μm ganglion cell and inner plexiform layer (GCIP) loss, and an average HCVA decrease of 0.22 dec. Based on a linear regression model, average GCIP loss amounted to -0.2 μm per day and started 8 days after onset. OCT outcomes but not VEP correlated well with all visual function measurements at follow-up. Structural and functional damage in 20 patients (40%) diagnosed de novo with multiple sclerosis (MS) and in 2 patients (4%) with positive myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) test did not differ from patients with idiopathic ON.CONCLUSIONS: Optic neuritis causes substantial retinal damage and vision loss independent of the underlying disease. Our study supports that GCIP damage starts closely to clinical onset. Good structure-function correlations between OCT and vision support the importance of OCT in monitoring acute ON. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |