Optical coherence tomography in acute optic neuritis: A population-based study

Autor: Svenja Specovius, Jakob Grauslund, Alexander U. Brandt, Clement Olesen, Hanna Zimmermann, Kerstin Soelberg, Jesper Mehlsen, Allan S B Neve, Friedemann Paul, Nasrin Asgari
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Visual acuity
Optic Neuritis
genetic structures
Denmark
Population
Nerve fiber layer
multiple sclerosis
Myelin oligodendrocyte glycoprotein
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Ophthalmology
medicine
Humans
autoimmune diseases
Optic neuritis
Prospective Studies
education
optic neuritis
education.field_of_study
optical coherence tomography
biology
business.industry
Multiple sclerosis
Retinal
General Medicine
Middle Aged
medicine.disease
eye diseases
Ganglion
medicine.anatomical_structure
Neurology
chemistry
030221 ophthalmology & optometry
biology.protein
myelin oligodendrocyte glycoprotein autoantibodies
Female
sense organs
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Tomography
Optical Coherence
Zdroj: Soelberg, K, Specovius, S, Zimmermann, H G, Grauslund, J, Mehlsen, J J, Olesen, C, Neve, A S B, Paul, F, Brandt, A U & Asgari, N 2018, ' Optical coherence tomography in acute optic neuritis : A population-based study ', Acta Neurologica Scandinavica, vol. 138, no. 6, pp. 566-573 . https://doi.org/10.1111/ane.13004
ISSN: 1600-0404
DOI: 10.1111/ane.13004
Popis: OBJECTIVES: To measure early structural damage caused by autoimmune inflammatory optic neuritis (ON) by optical coherence tomography (OCT) in a population-based cohort.METHODS: In a prospective population-based study over 24 months in Southern Denmark, patients diagnosed with acute ON and without prior diagnosis of a chronic neuroinflammatory disorder were included and examined with OCT, visual evoked potentials (VEP), visual fields, high contrast visual acuity (HCVA), and low contrast letter acuity (LCLA). Structural and functional outcomes were determined at 6-month follow-up based on interocular differences.RESULTS: The 50 included patients had on average 16.9 μm peripapillary retinal nerve fiber layer loss, 10.6 μm ganglion cell and inner plexiform layer (GCIP) loss, and an average HCVA decrease of 0.22 dec. Based on a linear regression model, average GCIP loss amounted to -0.2 μm per day and started 8 days after onset. OCT outcomes but not VEP correlated well with all visual function measurements at follow-up. Structural and functional damage in 20 patients (40%) diagnosed de novo with multiple sclerosis (MS) and in 2 patients (4%) with positive myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) test did not differ from patients with idiopathic ON.CONCLUSIONS: Optic neuritis causes substantial retinal damage and vision loss independent of the underlying disease. Our study supports that GCIP damage starts closely to clinical onset. Good structure-function correlations between OCT and vision support the importance of OCT in monitoring acute ON.
Databáze: OpenAIRE
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