| Autor: |
Jun Li, Jia-Bin Li, Fan-Ping Meng, Qinghua Meng, Mingxiang Zhang, Guo Zhang, Li-Ming Chen, Yi-Lan Zeng, Da-Zhi Zhang, Guiqiang Wang, Yi-Qi Liu, Hui Zhuang, Zong Zhang, Yanzhong Peng, Fuchun Zhang, Wei-Feng Liang, Li-Hua Huang, Zhanqing Zhang, Yu-Ping Chen, Ying-Xia Liu, Zhi-Qiang Zou, Jia Shang, Li-Hua Cao, Hai-Bin Yu, Hong-Lian Gui, Jiawen Li, Hong Zhao, Xian-Zhi Lou, Anlin Ma, Qing-Hua Shang, Rong Fan, Yu-Qiang Mi, Chi Zhang, Wan-Hua Ren, Wei-Feng Zhao, Shibin Xie, Zhi-Jin Wang, Jun Cheng, Zhang X, Lang Bai, Qing Xie, Hui Liu |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Background & Aims: Chronic hepatitis B (CHB) can cause liver fibrosis and lead to cirrhosis even cancer, antiviral therapy can reverse liver fibrosis with limited effect, thus we aimed to evaluate the effect of An-Luo-Hua-Xian pill (ALHX) on fibrosis regression in CHB patients treated with ETV.Methods: Treatment naïve patients with CHB from Oct 1st, 2013 to Dec 31st, 2020 were randomly treated with ETV alone or combined with ALHX (ETV+ALHX). Patients’ demographic, laboratory and liver histology data before and after 78 weeks of treatment were collected. Ishak fibrosis score (F) was used and fibrosis regression means F decreased ≥1 after treatment.Results: In total, 394 patients with a second liver biopsy after treatment were included in per-protocol population: 132 patients in ETV group and 262 patients in ETV+ALHX group. After 78 weeks of treatment, the fibrosis regression rate in the ETV+ALHX group were significantly higher than ETV group in baseline F≥3 patients: 124/211 (58.8%) verse 45/98 (45.9%), p=0.035. The degradation rate of liver stiffness measurement (LSM) is also consistent with it: 154/262 (73.0%) in ETV+ALHX group and 60/132 (61.2%) in ETV group, p=0.037. Logistic regression analysis showed that combined with ALHX was related to fibrosis regression (OR=1.94, p=0.018), and family history of hepatocellular carcinoma was on the contrary (OR=0.41, p=0.031).Conclusions: ETV combined with ALHX can significantly increase liver fibrosis regression in CHB patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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