Analysis of Association between Norepinephrine Transporter Gene Polymorphisms and Personality Traits of NEO-FFI in a Japanese Population
| Autor: | Maki Numajiri, Kazuhiko Iwahashi, Shin Narita, Eiji Yoshihara, Jun Ishigooka, Kenta Nagahori, Nobuyo Ohtani |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Genetics
medicine.medical_specialty Extraversion and introversion Norepinephrine transporter media_common.quotation_subject Gene polymorphism Neuroticism NEO-FFI Psychiatry and Mental health Reward dependence medicine Personality Original Article Big Five personality traits Allele Psychology Psychiatry Biological Psychiatry media_common Genetic association |
| Zdroj: | Psychiatry Investigation |
| ISSN: | 1976-3026 1738-3684 |
| Popis: | OBJECTIVE Norepinephrine is an important chemical messenger that is involved in mood and stress in humans, and is reabsorbed by the norepinephrine transporter (NET). According to Cloninger's theory, the noradrenergic system mediates the personality trait of reward dependence. Thus far, although association studies on NET gene polymorphisms and Cloninger's personality traits have been reported, they yielded inconsistent results. Therefore, in the present study we investigated whether or not the 1287G/A, -182T/C and -3081A/T polymorphisms of the NET gene (SLC6A2) are associated with reward dependence-related traits, as assessed by the five-factor model. METHODS After written informed consent was obtained from participants, the three NET gene polymorphisms were analyzed by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP), and personality was assessed by the Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) in 270 Japanese university students. RESULTS A significant relation was found between the -3081A/T functional promoter polymorphism and NEO-FFI scores: those with the T allele exhibited a lower extraversion (E) score than those without the T allele (Mann-Whitney U-test: z=-3.861, p |
| Databáze: | OpenAIRE |
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