Nasal symptoms, airway obstruction and disease severity in chronic obstructive pulmonary disease
| Autor: | John R. Hurst, Wayomi R. Perera, Philip Michael, Romana Kuchai, Tom M. A. Wilkinson, Jadwiga A. Wedzicha |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Spirometry medicine.medical_specialty Exacerbation Physiology Vital Capacity Severity of Illness Index Cohort Studies Pulmonary Disease Chronic Obstructive Acoustic rhinometry Forced Expiratory Volume Physiology (medical) Internal medicine otorhinolaryngologic diseases medicine Humans Aged Asthma COPD Lung medicine.diagnostic_test business.industry Smoking Respiratory disease General Medicine Middle Aged respiratory system Airway obstruction Respiration Disorders medicine.disease respiratory tract diseases Airway Obstruction medicine.anatomical_structure Anesthesia Cardiology Female business |
| Zdroj: | Clinical Physiology and Functional Imaging. 26:251-256 |
| ISSN: | 1475-097X 1475-0961 |
| DOI: | 10.1111/j.1475-097x.2006.00683.x |
| Popis: | Summary Background: Chronic obstructive pulmonary disease (COPD) is characterized by inflammation of the lung in association with airflow obstruction. There is increasing evidence of upper airway involvement in COPD and we have reported that this nasal inflammation is proportional to that in the lung. Given recognized relationships between lower airway inflammation and spirometric indices such as the Forced Expiratory Volume in one second (FEV1), we hypothesized that there may be a relationship between nasal obstruction and FEV1 in COPD. We also sought to investigate relationships between nasal symptoms and nasal patency in COPD. Methods: We assessed the nasal and pulmonary airways, using acoustic rhinometry and spirometry respectively, in 51 patients with COPD. Results: The presence of chronic nasal symptoms in COPD was associated with reduced nasal patency (6·04 cm2 symptoms vs. 9·55 cm2 no symptoms, at the second minimum cross-sectional area, P = 0·049). Nasal patency in COPD was inversely proportional to pulmonary airflow obstruction, and therefore to COPD disease severity (e.g. FEV1% predicted vs. second minimum cross-sectional area, r = 0·36, P = 0·009). Conclusions: The degree of nasal airway obstruction in COPD reflects the impairment to pulmonary airflow, and is greater in the presence of chronic nasal symptoms. This study provides further evidence of pan-airway involvement in COPD. |
| Databáze: | OpenAIRE |
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