Cardiovascular sequalae in uncomplicated COVID-19 survivors
| Autor: | Teresa Tong, Anthony Raymond Tam, Wing-Hon Lai, Polly Pang, Chu-Pak Lau, Ivan Hung, Ian C. K. Wong, Frankie C.C. Tam, Esther W. Chan, Jeffrey Chun-Yin Lee, Yee-Man Lau, Deborah Ho, Chung-Wah Siu, Hung-Fat Tse, Yat-Yin Lam, Mi Zhou, Chun-Ka Wong, Milky Oi Yan Tang, Ka-Chun Un, Ming-Yen Ng, YM Lau |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Viral Diseases Sinus bradycardia 030204 cardiovascular system & hematology Biochemistry Diagnostic Radiology Electrocardiography Ventricular Dysfunction Left 0302 clinical medicine Medical Conditions Heart Rate Atrial Fibrillation Ultrasound Imaging Natriuretic Peptide Brain Medicine and Health Sciences 030212 general & internal medicine Prospective Studies Survivors Multidisciplinary biology medicine.diagnostic_test Radiology and Imaging Atrial fibrillation Middle Aged Troponin Myocarditis Infectious Diseases Bioassays and Physiological Analysis Echocardiography Cardiology cardiovascular system Medicine Female medicine.symptom Arrhythmia Research Article Bradycardia Adult medicine.medical_specialty Heart Diseases Imaging Techniques Science Research and Analysis Methods 03 medical and health sciences Cardiac magnetic resonance imaging Diagnostic Medicine Intensive care Internal medicine medicine Humans cardiovascular diseases Aged business.industry SARS-CoV-2 Electrophysiological Techniques Biology and Life Sciences Proteins COVID-19 Covid 19 Arrhythmias Cardiac medicine.disease Survival Analysis Peptide Fragments Cytoskeletal Proteins biology.protein Cardiac Electrophysiology business Biomarkers |
| Zdroj: | PLoS ONE, Vol 16, Iss 2, p e0246732 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | BackgroundA high proportion of COVID-19 patients were reported to have cardiac involvements. Data pertaining to cardiac sequalae is of urgent importance to define subsequent cardiac surveillance.MethodsWe performed a systematic cardiac screening for 97 consecutive COVID-19 survivors including electrocardiogram (ECG), echocardiography, serum troponin and NT-proBNP assay 1–4 weeks after hospital discharge. Treadmill exercise test and cardiac magnetic resonance imaging (CMR) were performed according to initial screening results.ResultsThe mean age was 46.5 ± 18.6 years; 53.6% were men. All were classified with non-severe disease without overt cardiac manifestations and did not require intensive care. Median hospitalization stay was 17 days and median duration from discharge to screening was 11 days. Cardiac abnormalities were detected in 42.3% including sinus bradycardia (29.9%), newly detected T-wave abnormality (8.2%), elevated troponin level (6.2%), newly detected atrial fibrillation (1.0%), and newly detected left ventricular systolic dysfunction with elevated NT-proBNP level (1.0%). Significant sinus bradycardia with heart rate below 50 bpm was detected in 7.2% COVID-19 survivors, which appeared to be self-limiting and recovered over time. For COVID-19 survivors with persistent elevation of troponin level after discharge or newly detected T wave abnormality, echocardiography and CMR did not reveal any evidence of infarct, myocarditis, or left ventricular systolic dysfunction.ConclusionCardiac abnormality is common amongst COVID-survivors with mild disease, which is mostly self-limiting. Nonetheless, cardiac surveillance in form of ECG and/or serum biomarkers may be advisable to detect more severe cardiac involvement including atrial fibrillation and left ventricular dysfunction. |
| Databáze: | OpenAIRE |
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