Serum complement and familial combined hyperlipidemia
| Autor: | Jorma Viikari, Juha Vakkilainen, Marja-Riitta Taskinen, Leena Suurinkeroinen, Leena Peltonen, Päivi Pajukanta, Seppo Meri, Ilpo Nuotio, Christian Ehnholm, Kati Ylitalo, Kimmo Porkka |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcohol Drinking Apolipoprotein B Lipoproteins Hyperlipidemia Familial Combined 030204 cardiovascular system & hematology Body Mass Index Impaired glucose tolerance 03 medical and health sciences Acylation stimulating protein Sex Factors 0302 clinical medicine Internal medicine Hyperlipidemia Adipocytes medicine Humans Gonadal Steroid Hormones 030304 developmental biology 0303 health sciences Glucose tolerance test medicine.diagnostic_test biology Fatty Acids Smoking Complement C4 Blood Proteins Complement C3 Glucose Tolerance Test Middle Aged medicine.disease Lipids Complement system Endocrinology Postprandial Diabetes Mellitus Type 2 Complement C3a biology.protein Female Cardiology and Cardiovascular Medicine Lipoprotein |
| Zdroj: | Atherosclerosis. 129:271-277 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/s0021-9150(96)06054-6 |
| Popis: | Familial combined hyperlipidemia (FCHL) is one of the most common inherited lipid disorders. Resistance of adipocytes to the effects of acylation stimulating protein (ASP) may contribute to ineffective triglyceride synthesis and thereby prolonged postprandial lipemia and increased fatty acid flux to the liver seen in FCHL patients. Interestingly, ASP is identical to C3a-desArg, fragment of the third component of complement. We examined the relationships between serum levels of complement components C3 and C4 and markers of lipid and glucose metabolism in 11 large FCHL families (n = 53). Median serum C3 levels were 38% higher in affected compared to non-affected male FCHL family members (1.90 g/l vs. 1.38, P = 0.0027). The strongest correlations were observed between serum complement C3 and apolipoprotein B levels, reaching 0.77 in males. These relations were not confounded by obesity or impaired glucose tolerance. In conclusion, serum levels of the main complement components C3 and C4 correlated significantly with serum lipid levels. Further studies are needed to clarify the importance of disturbances in the complement system on the pathogenesis of FCHL and other lipid disorders. |
| Databáze: | OpenAIRE |
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