Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB(1) receptor knockout mice

Autor:	Assunta Imperato, M C Obinu, Catherine Ledent, Georg Andrees Bohme, Walter Fratta, Marc Parmentier, Maria Stefania Mascia
Rok vydání:	1999
Předmět:	Pharmacology Mice Knockout Morphine Chemistry medicine.medical_treatment Dopamine Receptors Drug Dopaminergic Nucleus accumbens Nucleus Accumbens Analgesics Opioid Mice Dopamine receptor D1 Dopamine receptor medicine Animals Cannabinoid Receptor Receptors Cannabinoid medicine.drug
Zdroj:	European journal of pharmacology. 383(3)
ISSN:	0014-2999
Popis:	Morphine (10 and 20 mg/kg, s.c.) does not modify dopamine release in the nucleus accumbens of cannabinoid CB(1) knock-out mice under conditions where it dose-dependently stimulates the release of dopamine in the corresponding wild-type mice. These results demonstrate that cannabinoid CB(1) receptors, regulate mesolimbic dopaminergic transmission in brain areas known to be involved in the reinforcing effects of morphine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbd4e58e62e535475c88fa4bcce6f17 https://pubmed.ncbi.nlm.nih.gov/10594337 Zobrazit plný text záznamu Full Text from ScienceDirect