Thymic epithelial cells expressed unusual follicular dendritic cell markers: Thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
| Autor: | Toshiyuki Mitsuya, Atsuko Masunaga, Akira Miyazaki, Hisayoshi Nakamura, Sanju Iwamoto, Mikio Masuda, Yoshitake T, Takashi Suzuki, Shuichi Suzuki, Rhosuke Usuda |
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| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Immunoelectron microscopy Thymus Gland Biology Pathology and Forensic Medicine Cytokeratin Biomarkers Tumor medicine Humans Microscopy Immunoelectron Follicular dendritic cells Epithelial Cells MALT lymphoma Lymphoma B-Cell Marginal Zone Thymus Neoplasms General Medicine Thymectomy Marginal zone medicine.disease Immunohistochemistry Epithelium medicine.anatomical_structure Lymphatic system Female Receptors Complement 3d Mucosa-associated lymphoid tissue Dendritic Cells Follicular |
| Zdroj: | Pathology International. 58:402-405 |
| ISSN: | 1440-1827 1320-5463 |
| DOI: | 10.1111/j.1440-1827.2008.02243.x |
| Popis: | Described herein is a case of thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Using immunohistochemical double staining it was found that most of the thymic lymphoid follicles in this case possessed cytokeratin-positive and follicular dendritic cell (FDC) marker-positive cells. Moreover, using immunoelectron microscopy it was confirmed that some of the double-positive cells were thymic epithelial cells. The candidate of cytokeratin subtype expressed on the double-positive cells was cytokeratin 1 (CK1), which was expressed only by the epithelium of Hassall's corpuscles in thymuses from age-matched patients with myasthenia gravis. The present case indicates a possibility that some thymic epithelial cells become FDC, although it was uncertain whether they were derived from the epithelia of Hassall's corpuscles or whether they were at the same differentiation stage as Hassall's corpuscles. |
| Databáze: | OpenAIRE |
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