Anticancer and apoptosis-inducing effects of quercetin in vitro and in vivo
| Autor: | George N. Tzanakakis, Ramin Rezaee, Aristides M. Tsatsakis, Mahmoud Hashemzaei, Amin Delarami Far, Dragana Nikitovic, Seyed Mohammad Taghdisi, Demetrios A. Spandidos, Dimitrios Kouretas, Reza Entezari Heravi, Sarvenaz Ekhtiari Sadegh, Kaveh Tabrizian, Konstantinos Tsarouhas, Arezoo Yari, Nikita Anisimov |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Cell Biology cancer treatment quercetin Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Line Tumor Neoplasms LNCaP medicine Animals Humans Annexin V/PI heterocyclic compounds Cell Proliferation MTT assay Cell growth apoptosis Articles General Medicine Cell cycle Xenograft Model Antitumor Assays Molecular biology Raji cell 030104 developmental biology medicine.anatomical_structure Oncology chemistry Cell culture Apoptosis 030220 oncology & carcinogenesis MCF-7 Cells Cancer research cytotoxicity Quercetin |
| Zdroj: | Oncology Reports |
| ISSN: | 1791-2431 1021-335X |
| Popis: | The present study focused on the elucidation of the putative anticancer potential of quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120 µM was assessed in vitro by MMT assay in 9 tumor cell lines (colon carcinoma CT-26 cells, prostate adenocarcinoma LNCaP cells, human prostate PC3 cells, pheocromocytoma PC12 cells, estrogen receptor-positive breast cancer MCF-7 cells, acute lymphoblastic leukemia MOLT-4 T-cells, human myeloma U266B1 cells, human lymphoid Raji cells and ovarian cancer CHO cells). Quercetin was found to induce the apoptosis of all the tested cancer cell lines at the utilized concentrations. Moreover, quercetin significantly induced the apoptosis of the CT-26, LNCaP, MOLT-4 and Raji cell lines, as compared to control group (P |
| Databáze: | OpenAIRE |
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