Phytosterols and Triterpenoids for Prevention and Treatment of Metabolic-related Liver Diseases and Hepatocellular Carcinoma
| Autor: | Gabriel Betanzos-Cabrera, Raquel Cariño-Cortés, Rosa A. Bobadilla-Lugo, Isabel Sánchez-Crisóstomo, Eduardo Fernández-Martínez |
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| Rok vydání: | 2019 |
| Předmět: |
Liver Cirrhosis
0301 basic medicine Carcinoma Hepatocellular Cirrhosis Pharmaceutical Science Disease Pharmacology Antioxidants 03 medical and health sciences Liver disease 0302 clinical medicine Non-alcoholic Fatty Liver Disease medicine Animals Humans Hepatoprotective Agent Metabolic Syndrome business.industry Liver Neoplasms Fatty liver Phytosterols medicine.disease Triterpenes 030104 developmental biology Liver 030220 oncology & carcinogenesis Hepatocellular carcinoma Steatohepatitis Metabolic syndrome business Biotechnology |
| Zdroj: | Current Pharmaceutical Biotechnology. 20:197-214 |
| ISSN: | 1389-2010 |
| DOI: | 10.2174/1389201020666190219122357 |
| Popis: | Background:Liver ailments are among the leading causes of death; they originate from viral infections, chronic alcoholism, and autoimmune illnesses, which may chronically be precursors of cirrhosis; furthermore, metabolic syndrome may worsen those hepatopathies or cause Non-alcoholic Fatty Liver Disease (NAFLD) that may advance to non-alcoholic steatohepatitis (NASH). Cirrhosis is the late-stage liver disease and can proceed to hepatocellular carcinoma (HCC). Pharmacological treatment options for liver diseases, cirrhosis, and HCC, are limited, expensive, and not wholly effective. The use of medicinal herbs and functional foods is growing around the world as natural resources of bioactive compounds that would set the basis for the development of new drugs.Review and Conclusion:Plant and food-derived sterols and triterpenoids (TTP) possess antioxidant, metabolic-regulating, immunomodulatory, and anti-inflammatory activities, as well as they are recognized as anticancer agents, suggesting their application strongly as an alternative therapy in some chronic diseases. Thus, it is interesting to review current reports about them as hepatoprotective agents, but also because they structurally resemble cholesterol, sexual hormones, corticosteroids and bile acids due to the presence of the steroid nucleus, so they all can share pharmacological properties through activating nuclear and membrane receptors. Therefore, sterols and TTP appear as a feasible option for the prevention and treatment of chronic metabolic-related liver diseases, cirrhosis, and HCC. |
| Databáze: | OpenAIRE |
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