Female under-representation in sepsis studies: a bibliometric analysis of systematic reviews and guidelines
| Autor: | Xavier Bonfill, Sami Petricola, Ivan Solà, Emilia Roy-Vallejo, Maria N Plana, Alba Antequera, Olaya Madrid-Pascual |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Clinical guidelines
Adult Data Analysis medicine.medical_specialty Bibliometric analysis Epidemiology Population Sex-related reporting Participation-to-prevalence ratio law.invention Sepsis 03 medical and health sciences 0302 clinical medicine Sex Factors Randomized controlled trial law medicine Humans Women 030212 general & internal medicine Social determinants of health education Randomized Controlled Trials as Topic Univariate analysis education.field_of_study business.industry Patient Selection Publications Gender Systematic reviews medicine.disease Observational Studies as Topic Systematic review Bibliometrics Family medicine Practice Guidelines as Topic Observational study Sex Female Patient Participation business 030217 neurology & neurosurgery Systematic Reviews as Topic |
| Zdroj: | JOURNAL OF CLINICAL EPIDEMIOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Institut dInvestigació Biomèdica Sant Pau (IIB Sant Pau) |
| ISSN: | 1878-5921 0895-4356 |
| Popis: | Objectives: The objective of the study was to assess female representation in primary studies underpinning recommendations from clinical guidelines and systematic reviews for sepsis treatment in adults. Study Design and Setting: We conducted a bibliometric study. We removed studies pertaining to sex-specific diseases and included quasirandomized, randomized clinical trials (RCTs), and observational studies. We analyzed the female participation-to-prevalence ratio (PPR). Results: We included 277 studies published between 1973 and 2017. For the 246 studies for which sex data were available, the share of female participation was 40%. Females overall were under-represented relative to their share of the sepsis population (PPR 0.78). Disaggregated results were reported by sex in 57 studies. In univariate analyses, non-intensive care unit setting and consideration of other social health determinants were significantly associated with greater female participation (P < 0.001 and P = 0.023, respectively). In regression models, studies published in 1996 or later were likely to report sex, while RCTs were unlikely to do so (P = 0.019 and P < 0.001, respectively). Conclusion: Our study points to female underenrollment in sepsis studies. Primary studies underpinning recommendations for sepsis have poorly reported their findings by sex. (C) 2020 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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