Reduced 3‐year risk of hospital admission and mortality after 12‐week resistance training of cirrhosis patients: A follow‐up of a randomized clinical trial

Autor: Luise Aamann, Gitte Dam, Peter Jepsen, Mette Borre, Aska Drljevic‐Nielsen, Kristian Overgaard, Henning Andersen, Hendrik Vilstrup, Niels Kristian Aagaard
Rok vydání: 2023
Předmět:
Zdroj: Aamann, L, Dam, G, Jepsen, P, Borre, M, Drljevic-Nielsen, A, Overgaard, K, Andersen, H, Vilstrup, H & Aagaard, N K 2023, ' Reduced 3-year risk of hospital admission and mortality after 12-week resistance training of cirrhosis patients : A follow-up of a randomized clinical trial ', Journal of Gastroenterology and Hepatology . https://doi.org/10.1111/jgh.16141
ISSN: 1440-1746
0815-9319
DOI: 10.1111/jgh.16141
Popis: Background and Aim: Physical activity confers health benefits in many diseases but remains almost unstudied for cirrhosis. We investigated whether a period of resistance training affects the subsequent long-term risk of hospitalization or mortality among patients with cirrhosis. Methods: The study includes 39 participants with cirrhosis Child–Pugh class A/B who participated in a prior clinical trial randomized to either resistance training three times per week for 12 weeks or a control group. We gathered data through medical records from trial entry and the following 3 years. The outcomes were time to first hospitalization and all-cause mortality. We used regression models to examine the associations between trial groups and outcomes, adjusting for Child–Pugh class, age, gender, and comorbidity. Results: Nine patients who trained and 15 controls were hospitalized, resulting in a lower risk of first hospitalization in the training group (adjusted subdistribution hazard ratio of 0.40, 95% confidence interval [CI] [0.17, 0.92]; P = 0.03). One patient who trained and six controls died, resulting in a lower all-cause mortality in the training group (adjusted hazard ratio of 0.06, 95% CI [0.01, 0.66]; P = 0.02). Conclusion: Twelve weeks of resistance training was associated with a reduced risk of first hospitalization and mortality among patients with cirrhosis Child–Pugh class A/B 3 years after trial entry. The mechanisms of this effect are not identified, and larger studies are warranted.
Databáze: OpenAIRE
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