p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice
| Autor: | Yukihiko Sugimoto, Akemichi Baba, Soken Tsuchiya, Kazuki Nagayasu, Atsushi Kasai, Mai Koumoto, Norihito Shintani, Ryota Hashimoto, Shota Tanaka, Tadayasu Ohkubo, Shintaro Higashi, Atsushi Ichikawa, Takuya Yoshida, Hitoshi Hashimoto, Kazuya Ikeda, Ken Ichi Hamagami, Shuhei Tomimoto, Takanobu Nakazawa, Yukio Ago, Atsuko Hayata-Takano, Naoki Inoue, Kazuhiko Katagi, Yusuke Onaka |
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| Rok vydání: | 2015 |
| Předmět: |
Genetically modified mouse
medicine.medical_specialty Biophysics Mice Transgenic Type 2 diabetes Carbohydrate metabolism Biology Diet High-Fat Biochemistry High fat fed Mice Basal (phylogenetics) Insulin-Secreting Cells Internal medicine medicine Animals Obesity Molecular Biology Mitosis geography geography.geographical_feature_category Pancreatic islets Cell Biology Islet medicine.disease Up-Regulation Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 2 |
| Zdroj: | Biochemical and Biophysical Research Communications. 461:612-617 |
| ISSN: | 0006-291X |
| Popis: | We examined the pancreatic function of p13 encoded by 1110001J03Rik, whose expression is decreased in pancreatic islets in high-fat-fed diabetic mice, by generating transgenic mice overexpressing p13 (p13-Tg) in pancreatic β-cells. p13-Tg mice showed normal basal glucose metabolism; however, under high-fat feeding, these animals showed augmented glucose-induced first-phase and total insulin secretion, improved glucose disposal, greater islet area and increased mitotic insulin-positive cells. In addition, high-fat diet-induced 4-hydroxynonenal immunoreactivity, a reliable marker and causative agent of lipid peroxidative stress, was significantly decreased in p13-Tg mouse islets. These results indicate that p13 is a novel pancreatic factor exerting multiple beneficial effects against type 2 diabetes. |
| Databáze: | OpenAIRE |
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