Psychological distress in men with prostate cancer receiving adjuvant androgen-deprivation therapy
| Autor: | Francesco Porpiglia, Alfredo Berruti, Luca Ostacoli, Pier Maria Furlan, Erica Sguazzotti, Sara Campagna, Roberto Mario Scarpa, Andrea Saini, Rocco Luigi Picci, Lucianna Russo, Luigi Dogliotti, Valentina Bertaglia, Cecilia Maria Cracco, Alessandra Tosco, Manuela Negro |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Sleep Wake Disorders Oncology androgen deprivation medicine.medical_specialty Urology medicine.medical_treatment Anxiety Hospital Anxiety and Depression Scale Pittsburgh Sleep Quality Index Androgen deprivation therapy Prostate cancer anxiety depression prostate cancer Quality of life Internal medicine Outcome Assessment Health Care Body Image medicine Humans Depression (differential diagnoses) Aged Aged 80 and over Depression Prostatectomy business.industry Prostatic Neoplasms Androgen Antagonists Middle Aged Prostate-Specific Antigen medicine.disease Radiation therapy Logistic Models Multivariate Analysis Quality of Life Neoplasm Grading business Stress Psychological |
| Zdroj: | Urologic Oncology: Seminars and Original Investigations. 31:352-358 |
| ISSN: | 1078-1439 |
| DOI: | 10.1016/j.urolonc.2011.02.005 |
| Popis: | Objectives To compare the occurrence of depression, anxiety, self body image perception, sleep disturbances, and diminished quality of life in prostate cancer patients undergoing adjuvant androgen-deprivation therapy (ADT) as opposed to patients in follow-up alone. Methods and materials Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index, Restless Legs Syndrome Study Group essential diagnostic criteria, Body Image Scale and Functional Assessment of Cancer Therapy Prostate were administered to consecutive prostate cancer patients who underwent radical prostatectomy or radiation therapy and are presently either under adjuvant ADT or included in a follow-up program. Results Of the 103 patients enrolled, 49 (47.6%) were receiving adjuvant ADT and 54 (52.4%) were not. Compared with the controls, the patients undergoing ADT showed higher levels of depression ( P = 0.002), worse self body image perception ( P = 0.001), worse quality of life ( P = 0.0001) and worse sleep quality ( P = 0.04). ADT was significantly associated with depression at multivariate analysis after adjustment for age, stage, Gleason score, as well as demographic and social variables ( P = 0.001). Depression scores showed a strong inverse correlation with quality of life scores ( P Conclusions Adjuvant ADT is associated with depression, worse quality of life, and altered self body image in prostate cancer patients. |
| Databáze: | OpenAIRE |
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