Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities
| Autor: | Mallesha Lingappa, D. G. Bhadregowda, Vathsala Deepu Channe Gowda, Mallikarjunaswamy Chandrashekaraiah |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Schiff base
Antioxidant biology Pyrimidine Article Subject medicine.medical_treatment General Chemistry Chloroacetyl chloride biology.organism_classification Antimicrobial In vitro Mycobacterium tuberculosis lcsh:Chemistry chemistry.chemical_compound chemistry lcsh:QD1-999 medicine Organic chemistry Amine gas treating |
| Zdroj: | Journal of Chemistry, Vol 2014 (2014) |
| ISSN: | 2090-9071 2090-9063 |
| Popis: | A series of 1-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-3-chloro-4-(2-mercaptoquinolin-3-yl)azetidin-2-one (7a-j) have been synthesized from the condensation of aromatic amines withN-phenylacetamide. The thione nucleus formed from 2-chloroquionoline-3-carbadehyde using sodium sulphide in dimethyl formamide (DMF) was followed by the reaction with pyrimidine amine to form the Schiff base intermediates. Attempt has been made to derive final azetidinone analogues from Schiff bases by using chloroacetyl chloride. The newly synthesized analogues were examined for the antimicrobial activity against some bacterial and fungal strains andin vitroantituberculosis activity against mycobacterium tuberculosis. These observations provide some predictions to design further antibacterial and antituberculosis active compounds prior to their synthesis according to molecular studies. |
| Databáze: | OpenAIRE |
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