Investigating the Dose-Response Relationship between Deep Breathing and Heart Rate Variability in Healthy Participants and Across-Days Reliability in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus

Autor:	Caroline Hundborg Liboriussen, Stine Søgaard Andersen, Sally Søgaard Andersen, Mette Kjeldsgaard Jensen, Mads Jochumsen, Salome Kristensen
Rok vydání:	2022
Předmět:	rheumatoid arthritis breathing systemic lupus erythematosus deep breathing heart rate variability vagus nerve stimulation neuromodulation dose-response reliability inflammation Biochemistry Analytical Chemistry Arthritis Rheumatoid Heart Rate Arthritis Rheumatoid/therapy Lupus Erythematosus Systemic Humans Electrical and Electronic Engineering Instrumentation Reproducibility of Results Lupus Erythematosus Systemic/complications Healthy Volunteers Atomic and Molecular Physics and Optics Heart Rate/physiology
Zdroj:	Sensors; Volume 22; Issue 18; Pages: 6849 Liboriussen, C H, Andersen, S S, Andersen, S S, Jensen, M K, Jochumsen, M & Kristensen, S 2022, ' Investigating the Dose-Response Relationship between Deep Breathing and Heart Rate Variability in Healthy Participants and Across-Days Reliability in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus ', Sensors (Basel, Switzerland), vol. 22, no. 18, 6849 . https://doi.org/10.3390/s22186849
ISSN:	1424-8220
DOI:	10.3390/s22186849
Popis:	Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) are associated with autonomic dysfunction, potentially through reduced vagus nerve tone. Vagus nerve stimulation has been proposed as an anti-inflammatory treatment, and it can be performed through deep breathing (DB) exercises. In this study, the dose-response relationship between DB exercises and heart rate variability (HRV) was investigated in healthy participants and reliability across days in patients with RA and SLE. On three separate days, 41 healthy participants performed DB for: 5, 15, or 30 min. On two separate days, 52 RA or SLE patients performed DB with the dose associated with the highest HRV increase in healthy participants. The HRV was estimated from ECG-recordings recorded prior and post the DB exercises. Increases in dose led to larger HRV-responses. Thirty minutes led to the largest HRV-response. In the RA and SLE patients, this dose increased the HRV-parameters consistently across the two days, indicating reliability. DB increases HRV in healthy participants and RA or SLE patients, which indicates stimulation of the vagus nerve. Of the tested durations, 30 min of DB was the optimal period of stimulation. A potential anti-inflammatory effect of DB exercises should be investigated in future studies.
Databáze:	OpenAIRE
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