N-Oleoyl-Dopamine Decreases Muscle Rigidity Induced by Reserpine in Rats
| Autor: | J Konieczny, M Pokorski, Edmund Przegaliński |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Reserpine Dopamine Immunology Hindlimb Catalepsy Antiparkinson Agents Levodopa Muscle tone Internal medicine medicine Haloperidol Animals Immunology and Allergy Rats Wistar Pharmacology Electromyography Chemistry medicine.disease Muscle Rigidity Rats medicine.anatomical_structure Endocrinology Reflex medicine.drug |
| Zdroj: | International Journal of Immunopathology and Pharmacology. 22:21-28 |
| ISSN: | 2058-7384 |
| Popis: | N-oleoyl-dopamine (OLDA), a product of condensation of oleic acid and dopamine (DA), is a bioactive compound that crosses the blood-brain barrier after systemic administration. The possibility arises that OLDA could have a potential role in treating DA-related disorders, such as Parkinson's disease (PD). In the present study we seek to determine whether OLDA would affect muscle tone and akinesia in two rat models of PD: the reserpine-evoked muscle rigidity and the reserpine- and haloperidol-induced catalepsy. We found that OLDA (20 mg/kg) significantly decreased muscle rigidity induced by reserpine (2.5 mg/kg), measured as an increased mechanical muscle resistance (MMG) in response to a passive extension and flexion of a rat hind limb at the ankle joint. Moreover, OLDA potently decreased the reserpine-enhanced tonic and reflex electromyographic (EMG) activities recorded before and during the movement, respectively. A lower dose of OLDA (10 mg/kg) failed to have appreciable effects. The reference compound L-DOPA (25 mg/kg) also attenuated the reserpine-increased MMG and EMG activities; the effects were, however, observed much later and were less prominent than those characteristic of OLDA. In contrast to the effects on muscle tone, OLDA (20 and 40 mg/kg) did not influence catalepsy induced by either reserpine (1.25 mg/kg) or haloperidol (0.5 mg/kg). In conclusion, the study demonstrates a novel biological action of N-oleoyl-dopamine consisting of lowering the reserpine-induced muscle rigidity. However, the lack of influence on akinesia suggests that the compound has myorelaxant rather than anti-Parkinsonian properties. |
| Databáze: | OpenAIRE |
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