Reactions of Auranofin and Its Pseudohalide Derivatives with Serum Albumin Investigated through ESI-Q-TOF MS
| Autor: | Alessandro Pratesi, Damiano Cirri, Lorenzo Ciofi, Luigi Messori |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Auranofin Stereochemistry Electrospray ionization Serum albumin 010402 general chemistry 01 natural sciences Adduct Inorganic Chemistry chemistry.chemical_compound Hydrogen Cyanide Nitriles medicine Physical and Theoretical Chemistry Bovine serum albumin Serum Albumin Molecular Structure biology 010405 organic chemistry Cytochrome c 0104 chemical sciences chemistry biology.protein Gold Lysozyme Time-of-flight mass spectrometry medicine.drug |
| Zdroj: | Inorganic Chemistry. 57:10507-10510 |
| ISSN: | 1520-510X 0020-1669 |
| Popis: | The reactions of auranofin and three pseudohalide derivatives with bovine serum albumin were explored by ESI-Q-TOF mass spectrometry; a detailed molecular description of the resulting adducts is achieved revealing even subtle differences in reactivity within this series of gold(I) complexes. Our study shows that this kind of investigative approach, formerly applied to the interactions of metal-based drugs with small model proteins of MW 10-15 kDa, e.g., cytochrome c and lysozyme, may now be extended with success to far larger proteins such as serum albumin (MW 66 kDa). |
| Databáze: | OpenAIRE |
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