| Autor: |
Frescas, David, Hall, Brandon M., Evguenia Strom, Virtuoso, Lauren P., Mahima Gupta, Gleiberman, Anatoli S., Rydkina, Elena, Balan, Vitaly, Vujcic, Slavoljub, Chernova, Olga B., Gudkov, Andrei V. |
| Rok vydání: |
2017 |
| Předmět: |
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| DOI: |
10.6084/m9.figshare.5146333.v1 |
| Popis: |
Age-related health decline has been attributed to the accumulation of senescent cells recognized in vivo by p16(Ink4a) expression. The pharmacological elimination of p16(Ink4a)-positive cells from the tissues of mice was shown to extend a healthy lifespan. Here, we describe a population of mesenchymal cells isolated from mice that are highly p16(INK4a)-positive are proficient in proliferation but lack other properties of cellular senescence. These data, along with earlier reports on p16(Ink4a)-positive macrophages, indicate that p16(Ink4a)-positive and senescent cell populations only partially intersect, therefore, extending the list of potential cellular targets for anti- aging therapies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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