The influence over a period of 8 years of patterns of prescribing palivizumab for patients with and without congenitally malformed hearts, and in admissions to paediatric intensive care
| Autor: | Jonathan Coutts, Alastair Turner, Colin B. Begg, Benjamin G. Smith |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Palivizumab
Heart Defects Congenital Pediatrics medicine.medical_specialty Time Factors Population Respiratory Syncytial Virus Infections Antibodies Monoclonal Humanized Intensive Care Units Pediatric Antiviral Agents Drug Prescriptions Paediatric intensive care unit Patient Admission Medicine Humans In patient Prospective Studies Medical prescription Practice Patterns Physicians' education education.field_of_study business.industry Paediatric intensive care Infant Newborn Antibodies Monoclonal General Medicine medicine.disease Respiratory Syncytial Viruses Vaccination Scotland Bronchiolitis Pediatrics Perinatology and Child Health Cardiology and Cardiovascular Medicine business medicine.drug Follow-Up Studies |
| Zdroj: | Cardiology in the young. 19(4) |
| ISSN: | 1467-1107 1047-9511 |
| Popis: | ObjectivesTo describe the pattern of prescribing for palivizumab in the Glasgow area over the period 1999 through 2007, and to compare recent prescribing to the current recommendations by the Joint Committee on Vaccination and Immunisation of the United Kingdom Department of Health. Our secondary objective was to describe admissions to paediatric intensive care in patients with respiratory syncytial virus receiving palivizumab.SettingTertiary children’s hospital out-patient immunisation clinic and paediatric intensive care unit.DesignProspective analysis of prescribing and admissions data for the period 1999 through 2007.Outcome measuresNumber of prescriptions and admissions to the paediatric intensive care unit.ResultsThe number of children receiving palivizumab annually initially rose more than 5-fold, from 17 in the season of 1999 and 2000 versus 115 in 2004 and 2005, although it has declined in the past 2 years, to 63 in 2006 and 2007, following publication of the recommendations of the Joint Committee on Vaccination and Immunisation established by the United Kingdom Department of Health. There has been no significant change in demographics of patients during this period. Prior to publication of these recommendations, 35 of 44 (80%) patients with congenitally malformed hearts who received palivizumab in the season of 2005 and 2006 deviated from the current recommendations, compared to 5 of 51 (10%) who received palivizumab for non-cardiac indications. No patients who received palivizumab required admission to the paediatric intensive care unit with proven respiratory syncytial virus infection over the 8 year period.ConclusionsThe number of children receiving palivizumab initially increased significantly, although it has now fallen following implementation of national recommendations. Much prescribing, particularly for children with congenitally malformed hearts, did not fulfil current recommendations. The absence of admissions to paediatric intensive care reflects the success of targeted immunisation in our population. |
| Databáze: | OpenAIRE |
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