EFFECT OF MONENSIN ON THE INVASIVENESS AND MULTIPLICATION OF LEGIONELLA-PNEUMOPHILA
| Autor: | C. Peluso, Paola Goldoni, L. Sinibaldi, L. Cattani, Nicola Orsi, M. Castellani Pastoris |
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| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Antibiotics Microbiology Legionella pneumophila HeLa chemistry.chemical_compound medicine Humans Monensin Infectivity biology General Medicine bacterial infections and mycoses biology.organism_classification In vitro respiratory tract diseases Microscopy Electron chemistry bacteria Bacteria Intracellular HeLa Cells |
| Popis: | Surmmary The polyether antibiotic monensin exhibited bacteriostatic activity against a clinical isolate of Legionella pneumophila in vitro. Experiments designed to test the effect of the compound on the invasiveness and multiplication of L. pneumophila in HeLa cells showed that, in the presence of the antibiotic, legionellas that penetrated the cells did not multiply. However, monensin did not alter the characteristics of phagosomes that contained ingested legionellas. In the presence of monensin, infected cells exhibited extensive vacuolation and a noticeable reduction in the number of intracellular micro-organisms was evident a few hours after infection. |
| Databáze: | OpenAIRE |
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