Evaluation of cardiac functions in children with Duchenne Muscular Dystrophy: A prospective case-control study
| Autor: | Ahmed Ahmed Allam, Shaimaa Mahmoud, Walaa Ibrahim Abd El-Halim, Abdelrahim Abdrabou Sadek, Mohammed Abd El-Aal |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Sinus tachycardia Duchenne muscular dystrophy Cardiomyopathy 030204 cardiovascular system & hematology Electrocardiography (ECG) 03 medical and health sciences 0302 clinical medicine Cardiac evaluations Internal medicine Troponin I Medicine Muscular dystrophy lcsh:R5-920 Ejection fraction business.industry medicine.disease Exact test Echocardiography Heart failure Duchenne muscular dystrophy (DMD) Cardiology Original Article medicine.symptom lcsh:Medicine (General) business 030217 neurology & neurosurgery |
| Zdroj: | Electronic Physician Electronic Physician, Vol 9, Iss 11, Pp 5732-5739 (2017) |
| ISSN: | 2008-5842 |
| DOI: | 10.19082/5732 |
| Popis: | Background: Duchenne muscular dystrophy (DMD) is the most common childhood form of muscular dystrophy. The incidence of cardiomyopathy in DMD increases with age, so its early detection is important because institution of cardioprotective medical therapies may slow adverse remodeling and attenuate heart failure symptoms in these patients. Objective: To assess the cardiac functions in children clinically suspected to have DMD. Methods: Over a one-year period, 28 male children aged from 3 to 18 years old, who met the criteria for diagnosis of DMD compared to 47 healthy controls children, were approached to participate in the study. The included children were subjected to full clinical examination, and blood samples were collected to determine creatinine phosphokinase (CPK), troponin I enzyme, myoglobin and lactate dehydrogenase (LDH) enzyme level. Echocardiography and 12-leads electrocardiogram (ECG) were also done for children in both groups. Data were analyzed using Independent-samples t-test, Mann-Whitney U, Chi square, and Fisher's exact test. Results: The mean age of the cases group was 7.29±3.24 years versus 8.06±2.86 years for controls. In DMD group, 25% had positive family history of DMD while 35.7% of them had positive consanguinity. All cases had elevated CPK level while CPK level in controls was normal (p |
| Databáze: | OpenAIRE |
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