Regulation of structural plasticity and neurogenesis during stress and diabetes; protective effects of glucocorticoid receptor antagonists
| Autor: | Lucassen, P.J., Fitzsimons, C.P., Vreugdenhil, E., Hu, P., Oomen, C., Revsin, Y., Joëls, M., de Kloet, E.R., Gravanis, A.G., Mellon, S.H. |
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| Přispěvatelé: | Structural and Functional Plasticity of the nervous system (SILS, FNWI) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
business.industry Neurogenesis Antagonist Hippocampus Mifepristone medicine.disease Glucocorticoid receptor Endocrinology Internal medicine Diabetes mellitus Structural plasticity medicine sense organs business Glucocorticoid hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Hormones in neurodegeneration, neuroprotection, and neurogenesis, 103-120 STARTPAGE=103;ENDPAGE=120;TITLE=Hormones in neurodegeneration, neuroprotection, and neurogenesis Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis |
| Popis: | In this chapter, we will review changes in structural plasticity of the adult hippocampus during stress and exposure to glucocorticoids (GCs). We further discuss the protective and normalizing role of glucocorticoid receptor (GR) antagonist treatment under these conditions and its implications for disorders such as depression and diabetes mellitus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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