Royal Sun Culinary-Medicinal Mushroom Agaricus brasiliensis (Agaricomycetes) as a Functional Food in Gestational Diabetes Mellitus Before and After Fetus Implantation
| Autor: | Thaisa B. Pickler, Angela Faustino Jozala, Marli Gerenutti, Fabia Judice Marques Viroel, Leticia F. Laurino, Denise Grotto, Isabella Ferreira Camargo, Raquel de Mendonça Rosa Castro, Erika Leão Ajala Caetano |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antioxidant endocrine system diseases Agaricus medicine.medical_treatment medicine.disease_cause Applied Microbiology and Biotechnology chemistry.chemical_compound Fetus Functional food Functional Food Pregnancy Internal medicine Drug Discovery medicine Animals Glycemic Pharmacology Triglyceride Cholesterol business.industry nutritional and metabolic diseases Streptozotocin medicine.disease Rats Gestational diabetes Diabetes Gestational Endocrinology chemistry Female business Oxidative stress medicine.drug |
| Zdroj: | International Journal of Medicinal Mushrooms. 23:15-27 |
| ISSN: | 1521-9437 |
| DOI: | 10.1615/intjmedmushrooms.2021039797 |
| Popis: | Through preclinical tests, this study evaluated the effects of Agaricus brasiliensis consumption in rats with streptozotocin (STZ)-induced gestational diabetes mellitus (GDM) and considered its potential as a functional food. The perinatal period was evaluated considering the daily exposure to A. brasiliensis before and after GDM induction (Abb and Aba, respectively). Nutritional characterization of A. brasiliensis was performed (centesimal composition, β-glucans, phenolic compounds, and antioxidant activity). Concerning maternal reproductive development, the parameters assessed were maternal weight, oral glucose tolerance, hemogram, biochemical markers, redox status in blood, biochemical markers in amniotic fluid, and reproductive performance. Moreover, embryofetal development was evaluated. A. brasiliensis reduced hyperglycemia before STZ induction and maintained levels similar to the GDM group after STZ induction. A. brasiliensis also reduced alanine aminotransferase, aspartate aminotransferase, triglyceride, and cholesterol levels and increased high-density lipoprotein levels. The mushroom also presented antioxidant activity, improving parameters of oxidative stress. Furthermore, it protected the conceptus from actions promoted by STZ concerning external abnormalities. Thus, daily intake of A. brasiliensis in GDM suggests its potential as a functional food because the nutritional characterization of this mushroom indicated important antioxidant activity, improving lipid and glycemic functions and preventing oxidative damage from STZ. |
| Databáze: | OpenAIRE |
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