Etoposide‐based treatment of adult HLH is associated with high biochemical response but poor survival outcomes

Autor:	Andre Mattman, David Dix, Luke Y.C. Chen, Leonie Naeije, Anna Hayden, Matthew C. Nicholson
Rok vydání:	2020
Předmět:	Oncology Ferritin medicine.medical_specialty biology business.industry Internal medicine biology.protein Medicine business Etoposide medicine.drug
Zdroj:	eJHaem. 1:277-280
ISSN:	2688-6146
DOI:	10.1002/jha2.57
Popis:	Etoposide-based treatment is the standard of care for adult HLH in many centers, yet there remains a paucity of data regarding treatment outcomes. We conducted a retrospective study of 23 adults treated with etoposide-based therapy compared to 10 pediatric HLH cases at a single center. At diagnosis, the median serum ferritin was 20,071 µg/L and 937 µg/L in adults and children, respectively; median sIL-2r was 14,524 U/mL and 4,478 U/mL. Biochemical response to treatment was high, with 21/23 adults achieving75% reduction in serum ferritin, but one year survival was only 7/21 compared to 7/10 in pediatric cases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada384ba34dd0a950c04fc3677c2c8c9 https://doi.org/10.1002/jha2.57 Zobrazit plný text záznamu Plný text