FLNA is implicated in pulmonary neuroendocrine tumors aggressiveness and progression
| Autor: | Marco Alloisio, Valeria Cambiaghi, Stefano Ferrero, Pierluigi Novellis, Andrea Lania, Eleonora Vitali, Ilena Boemi, Anna Spada, Lorenzo Rosso, Giovanna Mantovani, Giulia Veronesi |
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| Přispěvatelé: | Vitali, E, Boemi, I, Rosso, L, Cambiaghi, V, Novellis, P, Mantovani, G, Spada, A, Alloisio, M, Veronesi, G, Ferrero, S, Lania, Ag |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty cell migration Angiogenesis Filamin pulmonary neuroendocrine tumors 03 medical and health sciences 0302 clinical medicine Cyclin D1 Gene silencing FLNA Medicine Cell adhesion Cell growth business.industry Cell migration Filamin A cell proliferation 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research business Rap1 GTPase Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.20473 |
| Popis: | Pulmonary neuroendocrine tumors (PNTs) comprise different neoplasms, ranging from low grade carcinoids to the highly malignant small cell lung cancers. Several studies identified the cytoskeleton protein Filamin A (FLNA) as determinant in cancer progression and metastasis, but the role of FLNA in PNT aggressiveness and progression is still unknown. We evaluated FLNA expression in PNTs with different grade of differentiation, the role of FLNA in cell proliferation, colony formation, angiogenesis, cell adhesion and migration in PNT cell line (H727 cells) and primary cultures and the possible interaction between FLNA and Rap1-GTPase. FLNA is highly expressed in PNTs with high malignant grade. FLNA silencing reduces cyclin D1 levels (-51±5, p |
| Databáze: | OpenAIRE |
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