Proinflammatory parameters as CRP and IL-6 do not discriminate between post-PCI cardiac patients with and without exercise-induced ischemia as indicated by Tl-201 myocardial scintigraphy
| Autor: | Robert Hofmann, W. Maschek, Jörg Berg, Robert Pichler, Franz Leisch, Wolfgang Schimetta, Clemens Steinwender |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Myocardial Ischemia Ischemia Coronary Artery Disease Pathology and Forensic Medicine Proinflammatory cytokine Coronary artery disease chemistry.chemical_compound Risk Factors Internal medicine medicine Humans Prospective Studies Angioplasty Balloon Coronary Radionuclide Imaging Interleukin 6 Exercise biology Interleukin-6 business.industry C-reactive protein Percutaneous coronary intervention Neopterin General Medicine Middle Aged medicine.disease Thallium Radioisotopes C-Reactive Protein chemistry Conventional PCI Exercise Test biology.protein Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular Pathology. 13:299-305 |
| ISSN: | 1054-8807 |
| Popis: | Introduction Atherosclerosis is looked upon as an inflammatory disease. The production of proinflammatory markers may indicate activity in this inflammatory state. Methods We prospectively evaluated a range of proinflammatory serum parameters in 136 cardiac patients who had previously undergone percutaneous coronary intervention (PCI). Results By means of myocardial scintigraphy, an ischemia group (A; n =49) and a group with stable cardiovascular disease without exercise induced ischemia (B; n =87) were distinguished. Risk factors and lipoprotein profile of both groups were comparable. Serum levels of serum C-reactive protein (CRP), IL-6, sTNF-RI, IGF-I, neopterin, serotonin and prolactin did not present any significant difference between the two groups. Conclusions We conclude that measurement of these (inflammatory) parameters does not help to delineate post-PCI cardiac patients with and without exercise-induced ischemia. |
| Databáze: | OpenAIRE |
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