Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy

Autor: Chiara De Maddalena, Barbara Cavalli, Luca Meroni, Anna Bianchi Bosisio, Gianguglielmo Zehender, Massimo Galli, Mauro Moroni, Stefania Varchetta, Giuliano Rizzardini, Gianotto M, Chiara Colasante
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Zdroj: Scopus-Elsevier
Popis: We investigated the presence of human T-lymphotropic virus type 2 (HTLV-2) DNA in the peripheral blood mononuclear cell subsets obtained from 18 patients coinfected with human immunodeficiency virus type 1 and HTLV-2, 6 of whom also had predominantly sensory polyneuropathy (PSP). HTLV-2 DNA and RNA were found in CD8- and CD19-positive cells, and, for patients with PSP, in CD14-positive cells as well. Furthermore, the patients with PSP had higher proviral loads than those without PSP.
Databáze: OpenAIRE