Eosinophilic airway inflammation and the prognosis of childhood asthma
| Autor: | C. J. Lovett, Peter G. Gibson, Bruce Whitehead |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Hypersensitivity
Immediate Male Vital capacity medicine.medical_specialty Allergy Adolescent Vital Capacity Immunology Cohort Studies Forced Expiratory Volume Internal medicine Wheeze Eosinophilia Eosinophilic medicine Humans Immunology and Allergy Anti-Asthmatic Agents Child Lung Asthma Saline Solution Hypertonic business.industry Sputum Eosinophil Prognosis medicine.disease Respiratory Function Tests respiratory tract diseases medicine.anatomical_structure Quality of Life Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Clinical & Experimental Allergy. 37:1594-1601 |
| ISSN: | 1365-2222 0954-7894 |
| DOI: | 10.1111/j.1365-2222.2007.02839.x |
| Popis: | Summary Background Eosinophilic airway inflammation is a key pathophysiological feature of asthma that can predict treatment response. However, the prognostic value of sputum eosinophilia is not established. Objective The aim of this study was to determine the influence of induced sputum eosinophilia on the prognosis of childhood asthma. Methods A cohort of children with asthma was evaluated by induced sputum analysis at inception and classified as having either eosinophilic asthma (EA) (sputum eosinophils >2.5%) or non-eosinophilic asthma (NEA). After a mean follow-up period of 5 years, eligible subjects (n=83) were contacted and 69 subjects (33 EA, 36 NEA) evaluated. The children had a mean age of 15.9 years, and 61% were male. Results Children with EA reported more wheeze during the follow-up period (27% vs. 6% wheezed most years; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|