Scale-up of nature’s tissue weaving algorithms to engineer advanced functional materials
| Autor: | Ulf Knothe, Joanna L. Ng, Renee Whan, Melissa L. Knothe Tate, Lillian E. Knothe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Computer science Biocompatible Materials 02 engineering and technology Article Bone and Bones 03 medical and health sciences Tissue engineering Periosteum medicine Image Processing Computer-Assisted Animals Femur Weaving Photons Multidisciplinary Sheep biology Tissue Engineering Muscles Soft tissue 021001 nanoscience & nanotechnology Biocompatible material Elastin 030104 developmental biology medicine.anatomical_structure biology.protein Collagen 0210 nano-technology Algorithm Algorithms |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep40396 |
| Popis: | We are literally the stuff from which our tissue fabrics and their fibers are woven and spun. The arrangement of collagen, elastin and other structural proteins in space and time embodies our tissues and organs with amazing resilience and multifunctional smart properties. For example, the periosteum, a soft tissue sleeve that envelops all nonarticular bony surfaces of the body, comprises an inherently “smart” material that gives hard bones added strength under high impact loads. Yet a paucity of scalable bottom-up approaches stymies the harnessing of smart tissues’ biological, mechanical and organizational detail to create advanced functional materials. Here, a novel approach is established to scale up the multidimensional fiber patterns of natural soft tissue weaves for rapid prototyping of advanced functional materials. First second harmonic generation and two-photon excitation microscopy is used to map the microscopic three-dimensional (3D) alignment, composition and distribution of the collagen and elastin fibers of periosteum, the soft tissue sheath bounding all nonarticular bone surfaces in our bodies. Then, using engineering rendering software to scale up this natural tissue fabric, as well as multidimensional weaving algorithms, macroscopic tissue prototypes are created using a computer-controlled jacquard loom. The capacity to prototype scaled up architectures of natural fabrics provides a new avenue to create advanced functional materials. |
| Databáze: | OpenAIRE |
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