Mortality related to chronic hepatitis B and chronic hepatitis C in France: Evidence for the role of HIV coinfection and alcohol consumption

Autor: Nathalie Ganne, Jean-Claude Desenclos, Eric Jougla, Murielle Mechain, Elisabeth Delarocque-Astagneau, Denise Antona, Patrick Hillon, M. Bovet, F Péquignot, Tarik Asselah, Patrick Marcellin, Jean-Pierre Zarski
Přispěvatelé: Duperray, Alain, Centre de recherche biomédicale Bichat-Beaujon (CRB3), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hépatologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre d'épidémiologie sur les causes médicales de décès (CépiDc), Département des maladies infectieuses, Institut de Veille Sanitaire (INVS), Département de Gastroentérologie et hépatologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Service d'Hépato-Gastroentérologie, Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'hépato-gastroentérologie et cancérologie digestive (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)
Rok vydání: 2008
Předmět:
Adult
Male
medicine.medical_specialty
Alcohol Drinking
MESH: Hepatitis B
Chronic
HIV Infections
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
03 medical and health sciences
Liver disease
Hepatitis B
Chronic
0302 clinical medicine
Acquired immunodeficiency syndrome (AIDS)
Internal medicine
Epidemiology
medicine
Humans
030212 general & internal medicine
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
Aged
MESH: Aged
Hepatitis
MESH: Middle Aged
MESH: Humans
Hepatology
business.industry
Mortality rate
virus diseases
MESH: Adult
MESH: HIV Infections
Hepatitis C
Hepatitis C
Chronic
Middle Aged
Hepatitis B
medicine.disease
MESH: Male
digestive system diseases
MESH: Hepatitis C
Chronic
3. Good health
MESH: France
Transplantation
Immunology
Female
030211 gastroenterology & hepatology
France
business
MESH: Female
MESH: Alcohol Drinking
Zdroj: Journal of Hepatology
Journal of Hepatology, Elsevier, 2008, 48 (2), pp.200-7. ⟨10.1016/j.jhep.2007.09.010⟩
ISSN: 0168-8278
1600-0641
DOI: 10.1016/j.jhep.2007.09.010
Popis: International audience; BACKGROUND/AIMS: Mortality related to HCV and HBV infections was estimated in France. METHODS: A random sample (n=999) of death certificates was obtained from all death certificates listing HBV, HCV, hepatitis, liver disease, possible complication of cirrhosis, bacterial infection, HIV, or transplantation (n=65,000) in France in 2001. Physicians who reported the deaths were sent a questionnaire to identify how many deaths were related to HBV/HCV infection. Completed forms were independently analyzed by a panel of hepatologists. Death rates were estimated according to national population census data. RESULTS: Estimated annual number of deaths associated with HCV and HBV infection was 3618 and 1507, respectively (6.1 and 2.5 deaths per 100,000 inhabitants, respectively). Estimated number of deaths attributable to HCV or HBV infection was 2646 and 1327, respectively (4.5 and 2.2 deaths per 100,000 inhabitants, respectively). In the HCV infection group, 95 percent had cirrhosis; 33 percent had hepatocellular carcinoma (HCC). In the HBV infection group, 93 percent had cirrhosis; 35 percent had HCC. Eleven percent of deaths occurred in patients with HIV coinfection. Deaths related to HBV or HCV infection occurred at an earlier age in patients with a history of excessive alcohol consumption. CONCLUSIONS: In France, 4000-5000 deaths related to HCV and HBV infection occurred in 2001. Alcohol consumption and HIV infection were important co-factors. These data emphasize the need for ongoing, efficient public health programs that include screening, management, and counseling for HCV- and HBV-infected individuals.
Databáze: OpenAIRE
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