Juvenile myelomonocytic leukemia with prominent CD141+ myeloid dendritic cell differentiation

Autor:	Georgetta Blidaru, Hilda Ding, June Schlegelmilch, Rachel A. Egler, Rolla Abu-Arja, Howard J. Meyerson, Ebenezer S. Osei, Amad Awadallah
Rok vydání:	2017
Předmět:	0301 basic medicine Male Myeloid Myeloid dendritic cell differentiation Biopsy Thrombomodulin Population Spleen Biology CD13 Antigens Pathology and Forensic Medicine Antigens CD1 Proto-Oncogene Proteins p21(ras) 03 medical and health sciences 0302 clinical medicine medicine Biomarkers Tumor Neoplasm Humans Genetic Predisposition to Disease education Child Glycoproteins education.field_of_study Juvenile myelomonocytic leukemia Cell Differentiation Dendritic Cells medicine.disease Flow Cytometry Immunohistochemistry Haematopoiesis 030104 developmental biology medicine.anatomical_structure Phenotype Leukemia Myelomonocytic Juvenile Immunology Antigens Surface Mutation Bone marrow 030215 immunology
Zdroj:	Human pathology. 68
ISSN:	1532-8392
Popis:	Myeloid malignancies showing CD141+ myeloid dendritic cell (MDC) differentiation have not been documented. Here, we describe a patient with juvenile myelomonocytic leukemia in which a prominent CD141+ cell population was identified most consistent with CD141+ MDCs based on phenotypic similarity with normal CD141+ MDCs. Molecular studies demonstrated a KRAS mutation. The findings from the spleen and bone marrow are described. This is the first well-documented demonstration of CD141+ MDC differentiation of a hematopoietic neoplasm.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9a678d4ca7e88170af3fa55cbb019e https://pubmed.ncbi.nlm.nih.gov/28414089 Zobrazit plný text záznamu Full Text from ScienceDirect