Associations between serum uric acid and hepatobiliary-pancreatic cancer: A cohort study
Autor: | Teng Cai, Xun Li, Long Gao, Chongfei Huang, Jinduo Zhang, Yawen Lu, Bing Bai, Ningning Mi, Qiangsheng He, Yanyan Lin, Wenbo Meng, Ping Yue, Jun-Jun Huang, Jinqiu Yuan, Wenkang Fu, Chao Zhang |
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Rok vydání: | 2020 |
Předmět: |
Male
medicine.medical_specialty Pancreatic neoplasms Gastroenterology Cohort Studies 03 medical and health sciences 0302 clinical medicine Liver neoplasms Risk Factors Internal medicine Pancreatic cancer medicine Humans Prospective Studies Risk factor Gallbladder cancer Prospective cohort study business.industry Cancer General Medicine medicine.disease Gallbladder neoplasms Uric Acid Cancer registry Quartile 030220 oncology & carcinogenesis Prospective Study Female 030211 gastroenterology & hepatology Liver cancer business Biliary tract neoplasms |
Zdroj: | World Journal of Gastroenterology |
ISSN: | 1007-9327 |
Popis: | Background Uric acid is the end product of purine metabolism. Previous studies have found that serum uric acid (SUA) levels are associated with the total cancer risk. However, due to the dual effect of uric acid on cancer, the relationship between the SUA levels and most specific-site cancer remains unclear. Aim To investigate the associations between the SUA levels and incidence of hepatobiliary-pancreatic cancer. Methods In this prospective cohort study, 444462 participants free of cancer from the UK Biobank were included. The SUA levels were measured at baseline, and the incidence of hepatobiliary-pancreatic cancer was determined by contacting the cancer registry. The hazard ratios (HRs) and 95% confidence intervals (CIs) between the SUA levels and hepatobiliary-pancreatic cancer were investigated using multiple adjusted Cox regression models adjusted for potential confounders. Results In total, 920 participants developed liver, gallbladder, biliary tract or pancreatic cancer during a median of 6.6 yrs of follow-up. We found that the HR of pancreatic cancer in the highest SUA group was 1.77 (95%CI: 1.29-2.42) compared with that in the lowest group. After stratifying by gender, we further found that SUA was associated with an increased risk of pancreatic cancer only among the females (highest quartile vs lowest quartile HR 2.04, 95%CI: 1.35-3.08). Among the males, the SUA levels were positively associated with the gallbladder cancer risk (highest quartile vs lowest quartile HR 3.09, 95%CI: 1.28-7.46), but a U-shaped association with the liver cancer risk was observed (P-nonlinear = 0.03). Conclusion SUA is likely to have gender-specific effects on hepatobiliary-pancreatic cancer. High SUA levels are a risk factor for pancreatic cancer in females and gallbladder cancer in males. A U-shaped association with the liver cancer risk was identified. |
Databáze: | OpenAIRE |
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