A non-extraction HPLC method for the simultaneous determination of serum paracetamol and salicylate
| Autor: | Sandra J. Rainbow, C M Dawson, T.R. Tickner, T W M Wang |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
030213 general clinical medicine
Clinical Biochemistry Analgesic 030209 endocrinology & metabolism High-performance liquid chromatography Benzoates 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Antipyretic Hplc method Chromatography High Pressure Liquid Benzoic acid Acetaminophen Chromatography Chemistry Extraction (chemistry) General Medicine Reversed-phase chromatography Benzoic Acid Reference Standards Salicylates Salicylic acid medicine.drug |
| Zdroj: | Annals of clinical biochemistry. 25 |
| ISSN: | 0004-5632 |
| Popis: | A direct injection HPLC method for the sumultaneous measurement of serum paracetamol and salicylate is described using a Pinkerton internal surface reversed-phase column with benzoic acid as internal standard. The method is linear to at least 1000 mg/L for both drugs and shows good precision at levels of 62–500 mg/L. None of the drugs tested for interference affected the quantitation of either drug. In patient samples, the values obtained with this method correlated well with those from enzymatic paracetamol and Trinder salicylate methods. |
| Databáze: | OpenAIRE |
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