Translational research studies of erbB oncogenes: selection strategies for breast cancer treatment
| Autor: | Alf Beckmann, Gerd Assmann, Kurt S. Zänker, Burkhard Brandt, Christian Jackisch, Frank Gebhardt, Antje Rötger |
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| Rok vydání: | 1998 |
| Předmět: |
DNA Replication
Cancer Research Receptor ErbB-2 Gene Dosage Loss of Heterozygosity Breast Neoplasms Receptor tyrosine kinase Disease-Free Survival Metastasis Breast cancer ErbB Epidermal growth factor medicine Humans Copy-number variation Neoplasm Metastasis biology Genes erbB Gene Amplification DNA Neoplasm medicine.disease Prognosis ErbB Receptors Oncology Tumor progression biology.protein Cancer research Signal transduction |
| Zdroj: | Cancer letters. 118(2) |
| ISSN: | 0304-3835 |
| Popis: | Specific gene families, e.g. encoding members of signal transduction pathways, show a gene dosage sensitivity. We report on the determination of the gene dosages of egfr and c-erbB-2 in relation to the intratumoral concentration of the tyrosine kinase receptor protein EGFR and p185c-erbB-2 and the clinical outcome of breast cancer patients in a retrospective study. Prognostic unfavorable subgroups were determined in a life-table analysis by (a) an average gene copy number of egfr of less than 0.4 and greater than 1.6 and an intratumoral EGFR concentration of more than 56 fmol/mg, (b) an intratumoral p185c-erbB-2 concentration above 26 HNU/mg and (c) a quotient of egfr and c-erbB-2 average gene copy numbers of less than 0.15 and greater than 4.35. |
| Databáze: | OpenAIRE |
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