Microtubule-Associated Proteins: Structuring the Cytoskeleton

Autor: Satish Bodakuntla, A S Jijumon, Cristopher Villablanca, Carsten Janke, Christian Gonzalez-Billault
Přispěvatelé: Institut Curie [Paris], Stress génotoxiques et cancer, Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Paris-Sud - Paris 11 (UP11), Universidad de Chile = University of Chile [Santiago] (UCHILE)
Rok vydání: 2019
Předmět:
Zdroj: Trends in Cell Biology
Trends in Cell Biology, Elsevier, 2019, ⟨10.1016/j.tcb.2019.07.004⟩
ISSN: 0962-8924
DOI: 10.1016/j.tcb.2019.07.004
Popis: Microtubule-associated proteins (MAPs) were initially discovered as proteins that bind to and stabilize microtubules. Today, an ever-growing number of MAPs reveals a more complex picture of these proteins as organizers of the microtubule cytoskeleton that have a large variety of functions. MAPs enable microtubules to participate in a plethora of cellular processes such as the assembly of mitotic and meiotic spindles, neuronal development, and the formation of the ciliary axoneme. Although some subgroups of MAPs have been exhaustively characterized, a strikingly large number of MAPs remain barely characterized other than their interactions with microtubules. We provide a comprehensive view on the currently known MAPs in mammals. We discuss their molecular mechanisms and functions, as well as their physiological role and links to pathologies.
Databáze: OpenAIRE
Externí odkaz: