Histopathological effects of modern topical sealants on the liver surface after hepatectomy: an experimental swine study
| Autor: | Sara Mohammadi, Ali Majlesara, Arianeb Mehrabi, Elias Khajeh, Thomas Longerich, Hamidreza Fonouni, Lukas Konstantinidis, Arash Kashfi, Negin Gharabaghi, Yakup Kulu, Emre Aydogdu, Omid Ghamarnejad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Swine medicine.medical_treatment Administration Topical lcsh:Medicine Fibrin Tissue Adhesive Postoperative Hemorrhage Fibrinogen Gastroenterology Fibrin Article Hemostatics Resection 03 medical and health sciences Necrosis 0302 clinical medicine Internal medicine medicine Animals Hepatectomy Perioperative Period lcsh:Science Multidisciplinary biology business.industry Sealant lcsh:R Thrombin Liver regeneration Liver Regeneration Drug Combinations 030104 developmental biology Treatment Outcome Liver Cauterization biology.protein Hepatocytes Hepatocellular necrosis lcsh:Q Collagen business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The present study aimed to determine the impact of different sealant materials on histopathological changes to the liver surface after liver resection. Thirty-six landrace pigs underwent left anatomical hemihepatectomy and were assigned to a histopathological control group (HPC, n = 9) with no bleeding control, a clinically simulated control group (CSC, n = 9) with no sealant but bipolar cauterization and oversewing of the liver surface, and two treatment groups (n = 9 each) with a collagen-based sealant (CBS) or a fibrinogen-based sealant (FBS) on resection surface. After postoperative day 6, tissue samples were histologically examined. There were no significant differences in preoperative parameters between the groups. Fibrin production was higher in sealant groups compared with the HPC and CSC groups (both p |
| Databáze: | OpenAIRE |
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