Synthesis, computational, anticancerous and antiproliferative effects of some copper, manganese and zinc complexes with ligands derived from symmetrical 2,2’-diamino-4,4’-dimethyl-1,1’-biphenyl-salicylaldehyde
| Autor: | Taher S. Ababneh, Tareq M. A. Al-Shboul, Taghreed M. A. Jazzazi, Safa Daoud, Mohammad Jamal A. Shammout, Mohammad El-khateeb, Wamidh H. Talib, Aissar K. Tanash, Mohammad I. Alomari |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Biphenyl
spectroscopy symmetrical metal complexes 010405 organic chemistry General Chemical Engineering anticancerous chemistry.chemical_element Industrial chemistry General Chemistry Zinc Manganese 010402 general chemistry 01 natural sciences Combinatorial chemistry Copper 0104 chemical sciences chemistry.chemical_compound Chemistry chemistry Salicylaldehyde dft calculation antiproliferative tetradentate schiff base QD1-999 Biotechnology |
| Zdroj: | Polish Journal of Chemical Technology, Vol 23, Iss 1, Pp 7-15 (2021) |
| ISSN: | 1899-4741 |
| Popis: | Four new symmetrical Schiff bases derived from 2,2’-diamino-4,4’-dimethyl-1,1’-biphenyl-salicylaldehyde have been synthesized and characterized by elemental analysis and different spectroscopic techniques. The reaction of 2,2’-diamino-4,4’-dimethyl-1,1’-biphenyl with two equivalents of 5-tert-butyl-, 3,5-dinitro-, 3,5-dibromo- and 3-tert-butyl-salicylaldehyde yielded 2,2’-bis(5-tert-butyl-salicylideneamino)-4,4’-dimethyl-1,1’-biphenyl (A1) as well as the 3,5-dinitro- (A2), 3,5-dibromo- (A3) and 3-tert-butyl- (A4) substituted derivatives. The tetradentate ligands were then reacted with copper-, manganese- and zinc-acetate producing the tetra-coordinate metal complexes which were characterized by FTIR, UV-Visible spectroscopy, magnetic susceptibility and elemental analysis. Zinc complexes were characterized by 1H-NMR spectroscopy. Density functional theory (DFT) calculations at the B3LYP/6-31G(d) level of theory were carried out to fully optimize and examine the molecular geometries of complexes. Subsequently, IR vibrational and UV-Vis absorption spectra were computed and correlated with the observed values and the results are in good agreement with the experimental data. The anticancerous and antiproliferative activity of the A3 ligand and its metal complexes were determined. |
| Databáze: | OpenAIRE |
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